For me, the main issues are timezones and phone costs. Timezones, because no one will respect your hours if they don't conform to US ones. Phone costs, becaus

For me, the main issues are timezones and phone costs. Timezones, because no one will respect your hours if they don't conform to US ones. Phone costs, because people still have hour long teleconferences and those minutes add up. Skype is ok if the quality is good... if not, no one is sympathetic and just says "can you find a better phone?" The main general issues with telecommuting is that when someone says "I'm sure you've heard about Project X", you haven't.