> So much for the reductionist and simplistic "calories in and out" trope brought up frequently on here. That's how models work. They are simplified ideas to h

> So much for the reductionist and simplistic "calories in and out" trope brought up frequently on here. That's how models work. They are simplified ideas to help people understand things. They're not intended to be an all encompassing theory of everything. Just like "supply and demand" works but breaks down in certain circumstances. In general "calories in, calories out" does work. The body may adapt, various foods affect you differently, but CICO is not a heretical idea.