Short answer is yes. But you have to compensate by making the rotor blades longer or spinning them faster to get the same thrust. You can't let the net velocity

Short answer is yes. But you have to compensate by making the rotor blades longer or spinning them faster to get the same thrust. You can't let the net velocity (vector sum of tip velocity + aircraft velocity) reach supersonic or bad things happen. So you have practical considerations that lead to tradeoffs that determine the number of blades. The R22 and Cabri G2 are helicopters with basically the same mission, but one uses a 2-blade rotor, the other uses 3 blades. Different engineering choices, style, preferences.