3 ms·

With Prozac being one of the more mild antidepressants, one must imagine the results from even more refined drugs produced in recent decades. I also wonder how

With Prozac being one of the more mild antidepressants, one must imagine the results from even more refined drugs produced in recent decades. I also wonder how the mood stabilizers with antidepressant effects would intersect here. But, remember that anxiety is one of the most common side effects of Prozac and similar drugs. Perhaps for every patient positively affected you have another who's anxiety is actually amplified. Edit: Why downvote? This is both factual and informed by my anecdotal experience...

Construct 15y ago
Be careful. Anxiety is a common side effect only at the beginning of SSRI treatment. Once serotonin receptors down-regulate to accommodate the new levels of extra-cellular serotonin, steady-state is reached and the anxiety usually abates. Unfortunately, this causes many patients to abandon treatment before the the therapeutic value is apparent. This is one of the biggest obstacles in treating depression. Of course, there are always exceptions. However, most of the time you will find that those who complain about SSRIs inducing anxiety did not actually wait long enough for the effects to become apparent. Also, your suggestion that Prozac is one of the more mild SSRIs is completely backwards. Prozac is one of the earliest SSRIs and has a rather broad spectrum of receptor affinities. Newer SSRIs are more selective and have better side-effect profiles. Escitalopram is the gold standard here.
- hack_edu 15y ago
  I guess we must agree to disagree that its only a side effect in the beginning. My clinicians experience and mine (personal and experiences I've heard in Group Therapy) differ, though I'm happily on another anti-depressant that works for me. For what its worth, Prozac's effects were negligible for me. I still recommend it as a first treatment for those with symptoms. The same goes for my statement that Prozac is one of the more mild anti-depressants in terms in side effects. Its often the first prescribed, specifically for the reason that its effects (side and primary) are more mild, thus a safer place to baseline to start from.
- michaelochurch 15y ago
  He said that Prozac is one of the milder anti-depressants (not milder SSRIs). That's true. Prozac is coarse compared to the later SSRIs but not compared to the other categories of antidepressants (MAOI, tricyclic).

Construct 15y ago

Be careful. Anxiety is a common side effect only at the beginning of SSRI treatment. Once serotonin receptors down-regulate to accommodate the new levels of extra-cellular serotonin, steady-state is reached and the anxiety usually abates. Unfortunately, this causes many patients to abandon treatment before the the therapeutic value is apparent. This is one of the biggest obstacles in treating depression. Of course, there are always exceptions. However, most of the time you will find that those who complain about SSRIs inducing anxiety did not actually wait long enough for the effects to become apparent. Also, your suggestion that Prozac is one of the more mild SSRIs is completely backwards. Prozac is one of the earliest SSRIs and has a rather broad spectrum of receptor affinities. Newer SSRIs are more selective and have better side-effect profiles. Escitalopram is the gold standard here.

hack_edu 15y ago
I guess we must agree to disagree that its only a side effect in the beginning. My clinicians experience and mine (personal and experiences I've heard in Group Therapy) differ, though I'm happily on another anti-depressant that works for me. For what its worth, Prozac's effects were negligible for me. I still recommend it as a first treatment for those with symptoms. The same goes for my statement that Prozac is one of the more mild anti-depressants in terms in side effects. Its often the first prescribed, specifically for the reason that its effects (side and primary) are more mild, thus a safer place to baseline to start from.
michaelochurch 15y ago
He said that Prozac is one of the milder anti-depressants (not milder SSRIs). That's true. Prozac is coarse compared to the later SSRIs but not compared to the other categories of antidepressants (MAOI, tricyclic).