I was trying to keep it simple, but yes. It's not only the protein composition itself, but also the environment. It's like trying to solve an equation with 10

I was trying to keep it simple, but yes. It's not only the protein composition itself, but also the environment. It's like trying to solve an equation with 1000's of unknown variables and only 200 rules on variable interactions that are correct 90% of the time. Even just modeling a 100% pure aqueous environment and the interactions of water molecules is a massively complex problem.