8 ms·

> everyone, even the skinny folks, should be on GLP1 drugs Seriously? No thanks. Think I'll give you all a few decades to see what the long-term effects are li

by jfk13 4y ago

> everyone, even the skinny folks, should be on GLP1 drugs Seriously? No thanks. Think I'll give you all a few decades to see what the long-term effects are like, and let my body largely take care of itself except when specific medical issues indicate that an intervention is in order.

adamrezich 4y ago
it's always really strange to me whenever someone enthusiastically advocates that others use experimental drugs whose long-term side effects have not yet been discovered. if you want to try em yourself then go for it I guess, but I'm good thanks. it's interesting to take a step back and realize just how much pharmaceutical corporations have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens. maybe nothing will happen. maybe you'll get some mild nausea. maybe you'll suddenly develop an urge to kill yourself. but just try it and see what happens! ask your doctor if it's right for you (and if they get any kickbacks from it).
- sarchertech 4y ago
  It’s illegal for doctors to get kickbacks in the US. The most the average doctors gets is lunch provided to go to a lecture from a drug company. A free lunch isn’t enough to convince anyone to sit through an hour long lecture they weren’t already going to. But if you’re worried that your doctor is one of the small percentage of doctors who is paid to give those lectures, you can look them up. All payments are publicly available. You can easily find exactly how much they were paid, when, and for what. (The $20 in provided lunch is also required to be reported).
- pmarreck 4y ago
  > have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens This smells like you devoured some anti-vaxxer BS, btw. But for the record, these things go through a ton of testing and clinical trials. The reason science types are excited is BECAUSE this class of drug looks safe AND effective... based on the data. (And I'm also down 35+ lbs on tirzepatide, so far. This is the way.)
  - adamrezich 4y ago
    if expressing any less-than-positive opinions about pharmaceutical corporations is enough for you to make an immediate learned mental association with a popular dismissive political buzzword label, then I suggest asking yourself why exactly this is the first thing that came to mind, and what that might mean from a marketing perspective. I was prescribed 20mg daily of time-release amphetamines when I was 13, and that was 18 years ago. I have consumed somewhere in the range of 1300 grams of amphetamines in this time period. I have a dependency on it and I hate it. whose idea was it to give a 13-year-old amphetamines just because he spent too much time thinking about computers instead of focusing on middle school classwork. and a good mix of various antidepressants, none of which worked and all of which had unpleasant side effects. the medical system in this country, which its pharmaceutical corporations are fully complicit in, is far from pure and righteous and unquestionably benevolent. if marketing (or propaganda, depending on how you want to look at it) has conditioned you to believe otherwise, then I don't know what else I can tell you.
    - pmarreck 4y ago
      That's fair, but speaking as an occasional 15mg Adderall XR person for about 10 years now- You're not addicted to it. The downer when you go off it will take a few days (I take 2 days, you may take a day or 2 more) and will be a bitch, but it will pass. I go off mine on weekends so that I don't adapt to it.
      - adamrezich 4y ago
        this has not been my experience. I have tried for up to four days before and it's just miserable, it's like all the bad parts of being stoned and drunk and none of the good parts. when you've been on something since adolescence it's hard to break away. after I re-accrue time off after my wedding this coming summer I'm thinking about about taking a week off to try to go clean again but I'm deathly afraid of the sheer drop-off in productivity that will occur. I have lived more of my life on this drug than not, and getting off of it terrifies me, even though I hate it.
jostmey 4y ago
The only proven way to live longer and reduce your risk of essentially every disease is to reduce caloric intake. So unless you are underweight, the benefits could outweigh any side effects. I am not advocating that everyone take these drugs--but I understand why someone might suggest it
- UncleEntity 4y ago
  Why would I need a drug for that? I could probably just eat better (ie not one meal a day) and get “healthy”…not that I’m unhealthy now. Maybe, I prefer to live in denial. Three small meals a day and cut out the snacks and no drugs for me to take for the rest of my life.
- ravel-bar-foo 4y ago
  > The only proven way to live longer and reduce your risk of essentially every disease is to reduce caloric intake. Has this been proven in humans? The last review article I read mentioned that it was true for lab mice, but resulted in a suppressed immune response, which would result in early mortality for mice not living in a sterile (specific pathogen free; SPF) labitat.
  - leesec 4y ago
    >Has this been proven in humans? Seems like it but it still might not be worth it: https://slatestarcodex.com/2019/12/12/acc-does-calorie-restriction-slow-aging/ https://slatestarcodex.com/2019/12/12/acc-does-calorie-restr...
- onlyrealcuzzo 4y ago
  This is false. You burn ~50 calories per hour doing nothing. You're saying that the only way to live longer is to lay down and do nothing and IV ~50 calories per hour into your body. You're not going to live very long like that. You're obviously not going to live very long if you simply never eat and starve to death.
- jononomo 4y ago
  Why not just follow a diet of only beef, eggs, and liver? This is the most nutrient dense diet you can follow and as a result you'll reduce your calorie intake while increasing your feelings of satiety. Also, you'll resolve a dozen major and minor health conditions.
MaxHoppersGhost 4y ago
Being a young and very healthy person I felt this way about the COVID vaccine.
- komali2 4y ago
  Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccines, that's 2 decade old tech. Were you also worried about cold vaccines? Could this help alleviate some of your concerns? : https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/covid-19-vaccines-myth-versus-fact https://www.hopkinsmedicine.org/health/conditions-and-diseas...
  - tempestn 4y ago
    I'm with you except for the cold vaccines line. Did you mean flu vaccines?
    - komali2 4y ago
      yes, thank you
  - logicchains 4y ago
    >all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them This is misinformation. The normal process involves at least 4-5 years of observation to identify long-term side effects; you can't speed this up, as no matter how many people you test, it's not going to make long-term side effects manifest sooner. And while the technology has been around for 20 years, it certainly hasn't been trialed on humans until very recently, due to difficulty finding a safe delivery mechanism.
hawski 4y ago
I'm not exactly skinny as I have some muscle mass, still I'm pretty thin. I do not have to think about restricting calories and I'm still that way. I do not like to eat much sweets, I preferred a schnitzel since I was a child, so that's one thing. But sometimes I get a huge hunger when I feel my body trembling. I do think that if there would be famine I would just die. I also don't think it would be good for me to restrict caloric intake. There are certainly ways to make my diet healthier, but caloric restriction is not it.

by jfk13 4y ago

adamrezich 4y ago

it's always really strange to me whenever someone enthusiastically advocates that others use experimental drugs whose long-term side effects have not yet been discovered. if you want to try em yourself then go for it I guess, but I'm good thanks. it's interesting to take a step back and realize just how much pharmaceutical corporations have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens. maybe nothing will happen. maybe you'll get some mild nausea. maybe you'll suddenly develop an urge to kill yourself. but just try it and see what happens! ask your doctor if it's right for you (and if they get any kickbacks from it).

sarchertech 4y ago
It’s illegal for doctors to get kickbacks in the US. The most the average doctors gets is lunch provided to go to a lecture from a drug company. A free lunch isn’t enough to convince anyone to sit through an hour long lecture they weren’t already going to. But if you’re worried that your doctor is one of the small percentage of doctors who is paid to give those lectures, you can look them up. All payments are publicly available. You can easily find exactly how much they were paid, when, and for what. (The $20 in provided lunch is also required to be reported).
pmarreck 4y ago
> have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens This smells like you devoured some anti-vaxxer BS, btw. But for the record, these things go through a ton of testing and clinical trials. The reason science types are excited is BECAUSE this class of drug looks safe AND effective... based on the data. (And I'm also down 35+ lbs on tirzepatide, so far. This is the way.)
- adamrezich 4y ago
  if expressing any less-than-positive opinions about pharmaceutical corporations is enough for you to make an immediate learned mental association with a popular dismissive political buzzword label, then I suggest asking yourself why exactly this is the first thing that came to mind, and what that might mean from a marketing perspective. I was prescribed 20mg daily of time-release amphetamines when I was 13, and that was 18 years ago. I have consumed somewhere in the range of 1300 grams of amphetamines in this time period. I have a dependency on it and I hate it. whose idea was it to give a 13-year-old amphetamines just because he spent too much time thinking about computers instead of focusing on middle school classwork. and a good mix of various antidepressants, none of which worked and all of which had unpleasant side effects. the medical system in this country, which its pharmaceutical corporations are fully complicit in, is far from pure and righteous and unquestionably benevolent. if marketing (or propaganda, depending on how you want to look at it) has conditioned you to believe otherwise, then I don't know what else I can tell you.
  - pmarreck 4y ago
    That's fair, but speaking as an occasional 15mg Adderall XR person for about 10 years now- You're not addicted to it. The downer when you go off it will take a few days (I take 2 days, you may take a day or 2 more) and will be a bitch, but it will pass. I go off mine on weekends so that I don't adapt to it.
    - adamrezich 4y ago
      this has not been my experience. I have tried for up to four days before and it's just miserable, it's like all the bad parts of being stoned and drunk and none of the good parts. when you've been on something since adolescence it's hard to break away. after I re-accrue time off after my wedding this coming summer I'm thinking about about taking a week off to try to go clean again but I'm deathly afraid of the sheer drop-off in productivity that will occur. I have lived more of my life on this drug than not, and getting off of it terrifies me, even though I hate it.

jostmey 4y ago

The only proven way to live longer and reduce your risk of essentially every disease is to reduce caloric intake. So unless you are underweight, the benefits could outweigh any side effects. I am not advocating that everyone take these drugs--but I understand why someone might suggest it

UncleEntity 4y ago
Why would I need a drug for that? I could probably just eat better (ie not one meal a day) and get “healthy”…not that I’m unhealthy now. Maybe, I prefer to live in denial. Three small meals a day and cut out the snacks and no drugs for me to take for the rest of my life.
ravel-bar-foo 4y ago
> The only proven way to live longer and reduce your risk of essentially every disease is to reduce caloric intake. Has this been proven in humans? The last review article I read mentioned that it was true for lab mice, but resulted in a suppressed immune response, which would result in early mortality for mice not living in a sterile (specific pathogen free; SPF) labitat.
- leesec 4y ago
  >Has this been proven in humans? Seems like it but it still might not be worth it: https://slatestarcodex.com/2019/12/12/acc-does-calorie-restriction-slow-aging/ https://slatestarcodex.com/2019/12/12/acc-does-calorie-restr...
onlyrealcuzzo 4y ago
This is false. You burn ~50 calories per hour doing nothing. You're saying that the only way to live longer is to lay down and do nothing and IV ~50 calories per hour into your body. You're not going to live very long like that. You're obviously not going to live very long if you simply never eat and starve to death.
jononomo 4y ago
Why not just follow a diet of only beef, eggs, and liver? This is the most nutrient dense diet you can follow and as a result you'll reduce your calorie intake while increasing your feelings of satiety. Also, you'll resolve a dozen major and minor health conditions.

MaxHoppersGhost 4y ago

Being a young and very healthy person I felt this way about the COVID vaccine.

komali2 4y ago
Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccines, that's 2 decade old tech. Were you also worried about cold vaccines? Could this help alleviate some of your concerns? : https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/covid-19-vaccines-myth-versus-fact https://www.hopkinsmedicine.org/health/conditions-and-diseas...
- tempestn 4y ago
  I'm with you except for the cold vaccines line. Did you mean flu vaccines?
  - komali2 4y ago
    yes, thank you
- logicchains 4y ago
  >all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them This is misinformation. The normal process involves at least 4-5 years of observation to identify long-term side effects; you can't speed this up, as no matter how many people you test, it's not going to make long-term side effects manifest sooner. And while the technology has been around for 20 years, it certainly hasn't been trialed on humans until very recently, due to difficulty finding a safe delivery mechanism.

hawski 4y ago

I'm not exactly skinny as I have some muscle mass, still I'm pretty thin. I do not have to think about restricting calories and I'm still that way. I do not like to eat much sweets, I preferred a schnitzel since I was a child, so that's one thing. But sometimes I get a huge hunger when I feel my body trembling. I do think that if there would be famine I would just die. I also don't think it would be good for me to restrict caloric intake. There are certainly ways to make my diet healthier, but caloric restriction is not it.