Somewhat inevitable to use surrogates because you're going to take absolutely forever to get results on longevity (barring things with very strong negative effe

Somewhat inevitable to use surrogates because you're going to take absolutely forever to get results on longevity (barring things with very strong negative effects on longevity). Though communicating the difference between things that are only proven on surrogate markers and things shown to actually affect the real desired outcome is important, I agree.