6 ms·

I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation".

jboy55 4y ago
I take a GLP-1, I do not feel any of these effects unless I eat poorly. I'm not saying these side-effects don't happen, but they aren't guaranteed. Testing has also shown these aren't prevalent in the majority of users.
LordDragonfang 4y ago
Those are mostly just second-order symptoms of hypoglycemia/running a severe caloric deficit.
- mcculley 4y ago
  I have a lot of experience with fasting. I have never experienced those symptoms as a result of restricting calories.
  - hallway_monitor 4y ago
    In my experience, it seems like these effects may be more common in people who are not fat-adapted from low carb diets or some type of fasting.
  - mythhouse 4y ago
    > I have a lot of experience with fasting. > I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation". Did fasting help with weight control. Why are you considering these drugs ?
    - mcculley 4y ago
      Fasting does help me with weight control. I generally eat only one meal each day and I find this has many other benefits. I am not considering these drugs. I responded to "I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects."
  - sarchertech 4y ago
    Were you operating at a calorie deficit for a prolonged period though. I.e., were you fasting for weeks at a time?
    - mcculley 4y ago
      I have been eating only one meal per day deliberately for many years. I have fasted for up to 4 days. I seldom fast for more than one day. When I was doing keto, I never experienced the keto flu that many complain about. If these are the same symptoms, maybe the same benefits are achieved without taking the drug.
ianbutler 4y ago
You forgot the key part of "for the first 3 months" the assumption is that they largely tapered off for OP I think. That's an easy trade off for me personally.
- mcculley 4y ago
  I did not forget that. I am not going to risk brain fog for three months.
  - ianbutler 4y ago
    Okay that’s personal preference but the long term trade off seems to heavily out weigh some brain fog for a few months. Talking years of improved health.
    - Tepix 4y ago
      Not if brain fog is a symptom of brain injury.
      - ianbutler 4y ago
        Temporary brain fog, which is what is said here, doesn't indicate brain injury to me. You can get brain fog from a large caloric deficit before your body adjusts to it, which this by design, will induce.
    - mcculley 4y ago
      Have there been proven benefits beyond weight loss? I am responding to "I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects" and assertions about "longevity markers". I am not interested in taking a drug to lose weight. I am interested in improving my overall health, but I am not yet convinced that I should take this drug. The symptoms could be a sign that something bad is happening to the body.
      - ianbutler 4y ago
hackernewds 4y ago
despite that wouldn't just undernourishing the body lead to shorter lifespans not longer?
- mcculley 4y ago
  I have been hearing for at least 20 years that calorie restriction increases lifespan [0]. I have not seen compelling evidence of this, but I know a lot of people believe it. [0]: https://sitn.hms.harvard.edu/flash/2020/can-calorie-restriction-extend-your-lifespan/ https://sitn.hms.harvard.edu/flash/2020/can-calorie-restrict...
  - drcross 4y ago
    Please correct me if i'm wrong but wasn't the initial research on this conducted on animal models where they were essentially starved to the point where they went into hibernation mode? The point that I'd like to make is- if you think a comparison between hunter/gathers and the modern human is illustrative for a diet where our phenotype thrives best, sure, their food arrive at more irregular intervals than the modern human and they probably binged on what was in season at the time (which might give us pointers for our own diet) but I think the concept of perpetual calorie restriction as a full time human diet is infantile and quacky.
    - mcculley 4y ago
      This is exactly why I said, “I have not seen compelling evidence of this, but I know a lot of people believe it.”

I take a GLP-1, I do not feel any of these effects unless I eat poorly. I'm not saying these side-effects don't happen, but they aren't guaranteed. Testing has also shown these aren't prevalent in the majority of users.

LordDragonfang 4y ago

Those are mostly just second-order symptoms of hypoglycemia/running a severe caloric deficit.

mcculley 4y ago
I have a lot of experience with fasting. I have never experienced those symptoms as a result of restricting calories.
- hallway_monitor 4y ago
  In my experience, it seems like these effects may be more common in people who are not fat-adapted from low carb diets or some type of fasting.
- mythhouse 4y ago
  > I have a lot of experience with fasting. > I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation". Did fasting help with weight control. Why are you considering these drugs ?
  - mcculley 4y ago
    Fasting does help me with weight control. I generally eat only one meal each day and I find this has many other benefits. I am not considering these drugs. I responded to "I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects."
- sarchertech 4y ago
  Were you operating at a calorie deficit for a prolonged period though. I.e., were you fasting for weeks at a time?
  - mcculley 4y ago
    I have been eating only one meal per day deliberately for many years. I have fasted for up to 4 days. I seldom fast for more than one day. When I was doing keto, I never experienced the keto flu that many complain about. If these are the same symptoms, maybe the same benefits are achieved without taking the drug.

ianbutler 4y ago

You forgot the key part of "for the first 3 months" the assumption is that they largely tapered off for OP I think. That's an easy trade off for me personally.

mcculley 4y ago
I did not forget that. I am not going to risk brain fog for three months.
- ianbutler 4y ago
  Okay that’s personal preference but the long term trade off seems to heavily out weigh some brain fog for a few months. Talking years of improved health.
  - Tepix 4y ago
    Not if brain fog is a symptom of brain injury.
    - ianbutler 4y ago
      Temporary brain fog, which is what is said here, doesn't indicate brain injury to me. You can get brain fog from a large caloric deficit before your body adjusts to it, which this by design, will induce.
  - mcculley 4y ago
    Have there been proven benefits beyond weight loss? I am responding to "I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects" and assertions about "longevity markers". I am not interested in taking a drug to lose weight. I am interested in improving my overall health, but I am not yet convinced that I should take this drug. The symptoms could be a sign that something bad is happening to the body.
    - ianbutler 4y ago

hackernewds 4y ago

despite that wouldn't just undernourishing the body lead to shorter lifespans not longer?

mcculley 4y ago
I have been hearing for at least 20 years that calorie restriction increases lifespan [0]. I have not seen compelling evidence of this, but I know a lot of people believe it. [0]: https://sitn.hms.harvard.edu/flash/2020/can-calorie-restriction-extend-your-lifespan/ https://sitn.hms.harvard.edu/flash/2020/can-calorie-restrict...
- drcross 4y ago
  Please correct me if i'm wrong but wasn't the initial research on this conducted on animal models where they were essentially starved to the point where they went into hibernation mode? The point that I'd like to make is- if you think a comparison between hunter/gathers and the modern human is illustrative for a diet where our phenotype thrives best, sure, their food arrive at more irregular intervals than the modern human and they probably binged on what was in season at the time (which might give us pointers for our own diet) but I think the concept of perpetual calorie restriction as a full time human diet is infantile and quacky.
  - mcculley 4y ago
    This is exactly why I said, “I have not seen compelling evidence of this, but I know a lot of people believe it.”