4 ms·

I've never heard that caffeine prevents the clearing of adenosine receptors, a quick google didn't show anything with that side affect, do you have a particular

I've never heard that caffeine prevents the clearing of adenosine receptors, a quick google didn't show anything with that side affect, do you have a particular citation? I'd definitely change coffee consumption habits if that is the case.

andai 4y ago
Isn't that literally how caffeine works?
- oaktrout 4y ago
  More specifically I would say that's how caffeine tolerance works.
kseistrup 4y ago
You'll find a lot of references if you use a search engine to search for “caffeine and adenosine”. Here's the first result from my search: https://pubmed.ncbi.nlm.nih.gov/20164566/ https://pubmed.ncbi.nlm.nih.gov/20164566/
- Someone1234 4y ago
  That cite doesn't support what the person said above. Here is their claim again: > So if you drink caffeine in the first ~90minutes of waking then you dont actually clear the adenosine as well, and then when the caffeine hits it's half life (about 6 hours later) you'll feel tired again. Solution: let your body clear adenosine naturally before you consume caffeine. That is a very specific claim. Your cite is about caffeine antagonizing adenosine receptors, but what the comment above is talking about is that caffeine slows your body from clearing adenosine in your blood which is very different. I'd like to read a cite about the above quoted claim. Simplying googling "adenosine and caffeine" doesn't immediately support it, because again "antagonizing adenosine receptors" and "dont actually clear the adenosine as well" aren't remotely the same claim.
the-printer 4y ago
Personally, I learned this from Dr. Andrew Huberman… https://podclips.com/c/why-andrew-huberman-avoids-caffeine-for-152-hours-after-waking https://podclips.com/c/why-andrew-huberman-avoids-caffeine-f... https://www.reddit.com/r/AdvancedFitness/comments/qaq6z4/dr_andrew_huberman_because_caffeine_reduces/ https://www.reddit.com/r/AdvancedFitness/comments/qaq6z4/dr_... Sources should be in the show notes of the corresponding podcast episodes. Anecdotally: I can tell the difference.
- iLoveOncall 4y ago
  Podcasts and Reddit is the same as no source at all. If it's not a peer-reviewed published research (actually, multiple) it's not credible. It doesn't mean it's wrong, but presenting it as a fact like the OP did is wrong and potentially extremely harmful.
  - maerF0x0 4y ago
    > Podcasts and Reddit is the same as no source at all. Nah, c'mon, Most of us are unqualified to synthesize the dozens (if not hundreds) of sources it takes to be an expert in a field. Saying podcasts and reddit is the same as no source is like saying "People are no source" -- it entirely depends on the person. > Andrew D. Huberman is an American neuroscientist and tenured associate professor in the department of neurobiology and psychiatry and behavioral sciences at Stanford University School of Medicine That's a decently trustworthy source to trust for physiological information. I mean, do you force your GP to provide sources and then go read them before you take their advice? Even if you do, it's not advisable for the majority of people.
    - tmn 4y ago
      I was trying to formulate a reply and then saw yours. Well said
    - ilyt 4y ago
      Science or "science" around caffeine and food constantly bombards people with conflicting advice so I think that in this case it's fair to as more than "the guy said so on a podcast". It's akin sayin "he's developer for 10 years, clearly nothing he said about software is wrong", which would get you laughed out of the room
rolph 4y ago
i found this for you: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad01379 https://content.iospress.com/articles/journal-of-alzheimers-... despite the title, it is commonly cited re caffiene vs adenosine. the [PDF]is here: https://content.iospress.com/download/journal-of-alzheimers-disease/jad01379?id=journal-of-alzheimers-disease%2Fjad01379 https://content.iospress.com/download/journal-of-alzheimers-... [PDF]

andai 4y ago

Isn't that literally how caffeine works?

oaktrout 4y ago
More specifically I would say that's how caffeine tolerance works.

kseistrup 4y ago

You'll find a lot of references if you use a search engine to search for “caffeine and adenosine”. Here's the first result from my search: https://pubmed.ncbi.nlm.nih.gov/20164566/ https://pubmed.ncbi.nlm.nih.gov/20164566/

Someone1234 4y ago
That cite doesn't support what the person said above. Here is their claim again: > So if you drink caffeine in the first ~90minutes of waking then you dont actually clear the adenosine as well, and then when the caffeine hits it's half life (about 6 hours later) you'll feel tired again. Solution: let your body clear adenosine naturally before you consume caffeine. That is a very specific claim. Your cite is about caffeine antagonizing adenosine receptors, but what the comment above is talking about is that caffeine slows your body from clearing adenosine in your blood which is very different. I'd like to read a cite about the above quoted claim. Simplying googling "adenosine and caffeine" doesn't immediately support it, because again "antagonizing adenosine receptors" and "dont actually clear the adenosine as well" aren't remotely the same claim.

the-printer 4y ago

Personally, I learned this from Dr. Andrew Huberman… https://podclips.com/c/why-andrew-huberman-avoids-caffeine-for-152-hours-after-waking https://podclips.com/c/why-andrew-huberman-avoids-caffeine-f... https://www.reddit.com/r/AdvancedFitness/comments/qaq6z4/dr_andrew_huberman_because_caffeine_reduces/ https://www.reddit.com/r/AdvancedFitness/comments/qaq6z4/dr_... Sources should be in the show notes of the corresponding podcast episodes. Anecdotally: I can tell the difference.

iLoveOncall 4y ago
Podcasts and Reddit is the same as no source at all. If it's not a peer-reviewed published research (actually, multiple) it's not credible. It doesn't mean it's wrong, but presenting it as a fact like the OP did is wrong and potentially extremely harmful.
- maerF0x0 4y ago
  > Podcasts and Reddit is the same as no source at all. Nah, c'mon, Most of us are unqualified to synthesize the dozens (if not hundreds) of sources it takes to be an expert in a field. Saying podcasts and reddit is the same as no source is like saying "People are no source" -- it entirely depends on the person. > Andrew D. Huberman is an American neuroscientist and tenured associate professor in the department of neurobiology and psychiatry and behavioral sciences at Stanford University School of Medicine That's a decently trustworthy source to trust for physiological information. I mean, do you force your GP to provide sources and then go read them before you take their advice? Even if you do, it's not advisable for the majority of people.
  - tmn 4y ago
    I was trying to formulate a reply and then saw yours. Well said
  - ilyt 4y ago
    Science or "science" around caffeine and food constantly bombards people with conflicting advice so I think that in this case it's fair to as more than "the guy said so on a podcast". It's akin sayin "he's developer for 10 years, clearly nothing he said about software is wrong", which would get you laughed out of the room

rolph 4y ago

i found this for you: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad01379 https://content.iospress.com/articles/journal-of-alzheimers-... despite the title, it is commonly cited re caffiene vs adenosine. the [PDF]is here: https://content.iospress.com/download/journal-of-alzheimers-disease/jad01379?id=journal-of-alzheimers-disease%2Fjad01379 https://content.iospress.com/download/journal-of-alzheimers-... [PDF]