Pick a grid framework you like. I recommend either using the grid framework in Bootstrap[1] or Skeleton[2]. Skeleton I prefer because it has sensible typograp

Pick a grid framework you like. I recommend either using the grid framework in Bootstrap[1] or Skeleton[2]. Skeleton I prefer because it has sensible typography from the start, and slightly more padding than you usually find in grid frameworks. These will help you control spacing and layout pretty easily. As for color, you can find a palette that you like on colourlovers[3], then just work by varying what colors you want to use and when. [1] - http://twitter.github.com/bootstrap/ http://twitter.github.com/bootstrap/ [2] - http://getskeleton.com http://getskeleton.com [3] - http://colourlovers.com http://colourlovers.com