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"Ketamine transiently increased the power of baseline beta/gamma oscillations and decreased sensory-induced beta/gamma oscillations." "In addition, it disrupte

"Ketamine transiently increased the power of baseline beta/gamma oscillations and decreased sensory-induced beta/gamma oscillations." "In addition, it disrupted information transferability in both the somatosensory thalamus and the related cortex and decreased the sensory-induced thalamocortical connectivity in the broadband gamma range" Too dumb to understand, but I'm interested in therapeutic effects of ketamine. Is this good or bad?

tbalsam 4y ago
It's more of a purely mechanistic paper I believe, analogous to something like "transfer case wear patterns over 200k miles of normal passenger traffic shows shearing force of XYZ according to this nonlinear graph (which might imply ABC breakages, etc.)". Which therapeutic effects are you interested in? I'm not a doctor but could point out some potentially helpful information, depending.
- plusminusplus 4y ago
  Thanks for offering, more looking for a dumbed down version of this paper. I can't understand what the figures in the article represent our communicate.
  - tbalsam 4y ago
    Just pointing to my previous comment in the chain, specifically: I don't think one could reasonably simplify the content of this paper in a way that you'd find interesting for what you're looking for.
dmillar 4y ago
From the conclusion: *Because of their spatio-temporal structure and stereotyped pattern, sensory-evoked and induced gamma oscillations represent potential reliable and suitable variables for the development of innovative therapies preventing the psychotic transition.*
- plusminusplus 4y ago
  Thank you! Could we simplify that accurately as "this could potentially be therapeutic for people suffering from schizophrenia"?
  - tbalsam 4y ago
    Ketamine is often used as what's called a psychotomimetic to mimic the effects of schizophrenia in drug models of the disorder, so while technically maybe, the answer is "probably not". You generally don't want to add the drug used to model a disorder in the normal population to someone already having that disorder (unless we're wanting to do something like Xtreme Homeopathy: Lab Edition™ or something like that lol.)
    - plusminusplus 4y ago
      That's why it's shocking and exciting to see it be used to successfully treat depression, a chemical where very much the dose makes the poison I suppose

tbalsam 4y ago

It's more of a purely mechanistic paper I believe, analogous to something like "transfer case wear patterns over 200k miles of normal passenger traffic shows shearing force of XYZ according to this nonlinear graph (which might imply ABC breakages, etc.)". Which therapeutic effects are you interested in? I'm not a doctor but could point out some potentially helpful information, depending.

plusminusplus 4y ago
Thanks for offering, more looking for a dumbed down version of this paper. I can't understand what the figures in the article represent our communicate.
- tbalsam 4y ago
  Just pointing to my previous comment in the chain, specifically: I don't think one could reasonably simplify the content of this paper in a way that you'd find interesting for what you're looking for.

dmillar 4y ago

From the conclusion: *Because of their spatio-temporal structure and stereotyped pattern, sensory-evoked and induced gamma oscillations represent potential reliable and suitable variables for the development of innovative therapies preventing the psychotic transition.*

plusminusplus 4y ago
Thank you! Could we simplify that accurately as "this could potentially be therapeutic for people suffering from schizophrenia"?
- tbalsam 4y ago
  Ketamine is often used as what's called a psychotomimetic to mimic the effects of schizophrenia in drug models of the disorder, so while technically maybe, the answer is "probably not". You generally don't want to add the drug used to model a disorder in the normal population to someone already having that disorder (unless we're wanting to do something like Xtreme Homeopathy: Lab Edition™ or something like that lol.)
  - plusminusplus 4y ago
    That's why it's shocking and exciting to see it be used to successfully treat depression, a chemical where very much the dose makes the poison I suppose