3 ms·

Just one example: https://www.nbcnews.com/health/mental-health/psilocybin-mushroom-help-people-alcohol-use-disorder-rcna44180 https://www.nbcnews.com/health/me

by chaps 4y ago

Just one example: https://www.nbcnews.com/health/mental-health/psilocybin-mushroom-help-people-alcohol-use-disorder-rcna44180 https://www.nbcnews.com/health/mental-health/psilocybin-mush... "More than 80% of those who were given the psychedelic treatment had drastically reduced their drinking eight months after the study started, compared to just over 50% in the antihistamine control group, according to results published Wednesday in JAMA Psychiatry. At the end of the trial, half of those who received psilocybin had quit drinking altogether, compared to about one-quarter of those who were given the antihistamine."

gausswho 4y ago
that the placebo led to abstinence in 25% of cases makes me concerned about a selection bias in the pool
- SeanAnderson 4y ago
  What % would you expect to be affected by the placebo?
  - chairmanwow1 4y ago
    I think most adults are in a steady state for their habitual behaviors around diet / exercise / drinking / drugs. Would be surprised by anything larger than 10% change in control tbh
    - TylerE 4y ago
      FTA: "helped people with alcohol use disorder reduce drinking for at least eight months after their first treatments, results from the largest clinical trial of its kind show." This isn't a genpop study.
      - TylerE 4y ago
        Also, both prongs were given psychotherapy, also.
- boomboomsubban 4y ago
  Is it that hard to imagine twelve psychotherapy sessions convincing someone to quit drinking for eight months?
  - more_corn 4y ago
    Have you ever met an alcoholic?
    - boomboomsubban 4y ago
      Yes. I've also met former alcoholics, and people who quit for a while then started drinking again. Twelve weeks of therapy leading to eight months of sobriety for 25% of people does not seem surprising.
rhacker 4y ago
Sounds like anti-histamines are a good mechanism to stop drinking!
- chaps 4y ago
  No need for the silly reductionist snark there, friend. They were also given 12 psychotherapy sessions during the 8mo study.

by chaps 4y ago

gausswho 4y ago

that the placebo led to abstinence in 25% of cases makes me concerned about a selection bias in the pool

SeanAnderson 4y ago
What % would you expect to be affected by the placebo?
- chairmanwow1 4y ago
  I think most adults are in a steady state for their habitual behaviors around diet / exercise / drinking / drugs. Would be surprised by anything larger than 10% change in control tbh
  - TylerE 4y ago
    FTA: "helped people with alcohol use disorder reduce drinking for at least eight months after their first treatments, results from the largest clinical trial of its kind show." This isn't a genpop study.
    - TylerE 4y ago
      Also, both prongs were given psychotherapy, also.
boomboomsubban 4y ago
Is it that hard to imagine twelve psychotherapy sessions convincing someone to quit drinking for eight months?
- more_corn 4y ago
  Have you ever met an alcoholic?
  - boomboomsubban 4y ago
    Yes. I've also met former alcoholics, and people who quit for a while then started drinking again. Twelve weeks of therapy leading to eight months of sobriety for 25% of people does not seem surprising.

rhacker 4y ago

Sounds like anti-histamines are a good mechanism to stop drinking!

chaps 4y ago
No need for the silly reductionist snark there, friend. They were also given 12 psychotherapy sessions during the 8mo study.