You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex.

You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex. "Stop eating" is an input from the neocortex. It has very, very little impact on food drive. "Satiation/Nausia" is an input from primary metabolic regulatory systems. People that are 'only a little bit overweight' are usually in that state because they can't control their eating via the neocortex. You can't simply say "eat a little better"; you have to modify food drive. The signaling pathway this drug targets is the one that feed into food drive.