4 ms·

Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it f

Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?

wbarber 4y ago
Very likely so. I know of at least one study in which they are interested in determining if weight loss from semaglutide results in a similar decrease in cancer rates that they see in bariatric surgery patients. The drugs cause you to eat less and the mechanism of the drug may, in and of itself have some cardio protective effects. To get a drug approved for diabetics, you have to demonstrate it doesn’t cause cardiovascular issues because the comorbidity among diabetics is so high, and other drugs have a history of helping with blood sugars but causing cardiovascular issues. On those measures, iirc, semaglutide specifically showed my that the treatment group saw a significant reduction in cardiovascular events. I’m on mobile so can’t provide links at the moment.
causi 4y ago
As long as it doesn't damage those things by itself, either it will help them or we're totally wrong about what causes them.
- deleted 4y ago
  [deleted]
jcampbell1 4y ago
Dulaglutide is a drug in the same class that has been around longer there is a modest improvement for cardiovascular events. 5.4 years on the drug: https://pubmed.ncbi.nlm.nih.gov/31189511/ https://pubmed.ncbi.nlm.nih.gov/31189511/
- SamoyedFurFluff 4y ago
  Your link says “ in type 2 diabetes” in the title. I’m interested in non-diabetics, given this is going to be approved purely to unfat people without diabetes.
  - jcampbell1 4y ago
    I had the same curiosity as you but realized there can’t possibly be any long term studies because this class is new, and very new for weight loss. I just searched for the longest term study for the class.

Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?

wbarber 4y ago

Very likely so. I know of at least one study in which they are interested in determining if weight loss from semaglutide results in a similar decrease in cancer rates that they see in bariatric surgery patients. The drugs cause you to eat less and the mechanism of the drug may, in and of itself have some cardio protective effects. To get a drug approved for diabetics, you have to demonstrate it doesn’t cause cardiovascular issues because the comorbidity among diabetics is so high, and other drugs have a history of helping with blood sugars but causing cardiovascular issues. On those measures, iirc, semaglutide specifically showed my that the treatment group saw a significant reduction in cardiovascular events. I’m on mobile so can’t provide links at the moment.

causi 4y ago

As long as it doesn't damage those things by itself, either it will help them or we're totally wrong about what causes them.

deleted 4y ago
[deleted]

jcampbell1 4y ago

Dulaglutide is a drug in the same class that has been around longer there is a modest improvement for cardiovascular events. 5.4 years on the drug: https://pubmed.ncbi.nlm.nih.gov/31189511/ https://pubmed.ncbi.nlm.nih.gov/31189511/

SamoyedFurFluff 4y ago
Your link says “ in type 2 diabetes” in the title. I’m interested in non-diabetics, given this is going to be approved purely to unfat people without diabetes.
- jcampbell1 4y ago
  I had the same curiosity as you but realized there can’t possibly be any long term studies because this class is new, and very new for weight loss. I just searched for the longest term study for the class.