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Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using

Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using these drugs I can forsee many people who are only a bit overweight taking this when just eating better and working out would be so much better for them. [1] https://youtu.be/hcNTHLdH5QE https://youtu.be/hcNTHLdH5QE

pixl97 4y ago
The number of overweight people and diabetics far exceeds the number of celebrities out there. I think it's just demand driven by media exposure that is the issue
toomuchtodo 4y ago
Eating better and working out is hard. If the medication can get you a similar outcome with minimal side effects, that seems like a prudent protocol to prescribe. If it’s determined to be safe (statistically), why not? Might only be necessary until we can inexpensively synthesize miR-1: https://news.ycombinator.com/item?id=34196488 https://news.ycombinator.com/item?id=34196488
- Steven420 4y ago
  Unfortunately there aren't any shortcuts to good health
  - johncearls 4y ago
    Apparently there is now.
    - muldvarp 4y ago
      Exercise and diet have positive health effects other than losing weight. Many people with normal weight according to BMI still have an unhealthy body fat percentage. That said, if this drug can keep its promise it will have an enormous positive effect on public health.
  - astrange 4y ago
    If you’re regularly doing something unhealthy (like smoking or eating lead paint chips), stopping that is both good for you and a shortcut.
  - 9991 4y ago
    How do you know that?
  - EamonnMR 4y ago
    My understanding is that the way the drug works is by improving your diet.
- kiba 4y ago
  Why not both? A healthy lifestyle combined with pills that work.
  - tjohns 4y ago
    If you're living a healthy lifestyle, then you probably don't need pills to lose weight. We know diet and exercise (with an emphasis on the diet) will yield weight loss, if it's maintained. However, that's a big if. Behavior modification is hard. There are both physiological and emotional factors that need to be addressed, and cause many attempts at weight loss to fail. The drugs are a second line treatment when behavior modification fails. (And that said, exercise is still important. Overweight or not, it has a massive impact on longevity, physical health, and mental health.)
scythe 4y ago
If your BMI is over 35 (around 1 in 6 adults IIRC) it can make it hard to exercise. A little push in the right direction may be indicated.
- astrange 4y ago
  Exercise is also counterproductive for weight loss since it makes you hungrier, which makes people not compliant with their diets.
anonuser123456 4y ago
You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex. "Stop eating" is an input from the neocortex. It has very, very little impact on food drive. "Satiation/Nausia" is an input from primary metabolic regulatory systems. People that are 'only a little bit overweight' are usually in that state because they can't control their eating via the neocortex. You can't simply say "eat a little better"; you have to modify food drive. The signaling pathway this drug targets is the one that feed into food drive.
- andreareina 4y ago
  Eating better effects satiety.

pixl97 4y ago

The number of overweight people and diabetics far exceeds the number of celebrities out there. I think it's just demand driven by media exposure that is the issue

toomuchtodo 4y ago

Eating better and working out is hard. If the medication can get you a similar outcome with minimal side effects, that seems like a prudent protocol to prescribe. If it’s determined to be safe (statistically), why not? Might only be necessary until we can inexpensively synthesize miR-1: https://news.ycombinator.com/item?id=34196488 https://news.ycombinator.com/item?id=34196488

Steven420 4y ago
Unfortunately there aren't any shortcuts to good health
- johncearls 4y ago
  Apparently there is now.
  - muldvarp 4y ago
    Exercise and diet have positive health effects other than losing weight. Many people with normal weight according to BMI still have an unhealthy body fat percentage. That said, if this drug can keep its promise it will have an enormous positive effect on public health.
- astrange 4y ago
  If you’re regularly doing something unhealthy (like smoking or eating lead paint chips), stopping that is both good for you and a shortcut.
- 9991 4y ago
  How do you know that?
- EamonnMR 4y ago
  My understanding is that the way the drug works is by improving your diet.
kiba 4y ago
Why not both? A healthy lifestyle combined with pills that work.
- tjohns 4y ago
  If you're living a healthy lifestyle, then you probably don't need pills to lose weight. We know diet and exercise (with an emphasis on the diet) will yield weight loss, if it's maintained. However, that's a big if. Behavior modification is hard. There are both physiological and emotional factors that need to be addressed, and cause many attempts at weight loss to fail. The drugs are a second line treatment when behavior modification fails. (And that said, exercise is still important. Overweight or not, it has a massive impact on longevity, physical health, and mental health.)

scythe 4y ago

If your BMI is over 35 (around 1 in 6 adults IIRC) it can make it hard to exercise. A little push in the right direction may be indicated.

astrange 4y ago
Exercise is also counterproductive for weight loss since it makes you hungrier, which makes people not compliant with their diets.

anonuser123456 4y ago

You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex. "Stop eating" is an input from the neocortex. It has very, very little impact on food drive. "Satiation/Nausia" is an input from primary metabolic regulatory systems. People that are 'only a little bit overweight' are usually in that state because they can't control their eating via the neocortex. You can't simply say "eat a little better"; you have to modify food drive. The signaling pathway this drug targets is the one that feed into food drive.

andreareina 4y ago
Eating better effects satiety.