3 ms·
>We additionally show that HCQ exerts dose-dependent effects on late long-term potentiation (LTP) and rescues impaired hippocampal synaptic plasticity prior to
by maerF0x0 4y ago
>We additionally show that HCQ exerts dose-dependent effects on late long-term potentiation (LTP) and rescues impaired hippocampal synaptic plasticity prior to significant accumulation of amyloid plaques and neurodegeneration in APP/PS1 mice.
iirc (I am not qualified!!) Alzheimers relates to plaques in our brain, and this sounds to me like it fixes a precursor to the plaque accumulation (the loss of plasticity?)
- pelorat 4y agoThe plaques are a side effect of something we don't understand yet. Treating the plaque or slowing it is not a solution, we need to find and fix the cause.
- emodendroket 4y agoQuite apart from the validity of this study, isn’t a purely palliative measure still valuable?
- mattkrause 4y agoLiterally billions of dollars has been spent, futilely, on the idea that removing plaques would stop/reverse the symptoms of Alzheimer's Disease. This "amyloid hypothesis" has not been a smashing success, to put in mildly.
- ummonk 4y agoIt's not clear that treating amyloid plaque is actually palliative for Alzheimer's patients.