> Indigenous peoples of mesoamerica OK, but Pine Ridge is in North America. There could have been enough isolation in pre-Columbian times for north American i

> Indigenous peoples of mesoamerica OK, but Pine Ridge is in North America. There could have been enough isolation in pre-Columbian times for north American indigenous to evolve a different alcohol response from mesoamericans. Like I said: I am not an expert, and I have no idea whether this hypothesis is true or not. I'm just not aware of any facts that would rule it out.