3 ms·

In the linked report, the organ distribution of the LNPs is given in a table that spans two pages (pages 16-17 of the PDF corresponding to pages 6-7 in the repo

In the linked report, the organ distribution of the LNPs is given in a table that spans two pages (pages 16-17 of the PDF corresponding to pages 6-7 in the report's internal numbering). After 48 hours, only 24.6% of the lipids from the LNPs in the rodents' doses had remained at the injection site. The liver ended up with 16.2% and the spleen with slightly in excess of 1%. The remainder (nearly 60%) was widely distributed. The table has values for specific organs and tissues.

z7 4y ago
Yeah, but I'm told: >Only <1% of the injected mRNA vaccine got into the ovaries, adrenal glands, heart, brain, and other tissues at 48-hour. >Most of the vaccine remained in the injection site and went into the liver, “suggesting these LNPs may be eliminated mostly via hepatic [liver] clearance route,” Prof. Al-Ahmad wrote. >the dose the Japanese study used is very high when controlled for weight; that is, 18–35-times higher than what is injected into humans. >The Japanese biodistribution study results are consistent with Pfizer’s that was submitted to the European Medicines Agency (EMA) in February 2021. >Pfizer also found that the LNP-encapsulated mRNA vaccine was mainly metabolized in the liver and did not enter other tissues easily. They also noted no effects on fertility or ovarian functions. >For the Moderna mRNA vaccine, the EMA assessment report has previously released its biodistribution data that also finds no cause for concern. And then the author points out the absence of evidence regarding fertility risks: >Even if the mRNA vaccines did enter the ovaries in tiny amounts, there’s no evidence that ovarian cells can translate the mRNA into spike proteins. Even if ovarian cells somehow managed to manufacture some spike proteins, there’s no evidence that this can harm the ovaries. Maybe the spike proteins expressed on ovarian cells degrade within hours or days and disappear in a few days. Animal studies have shown that cells that take up the mRNA vaccine only express the mRNA-encoded proteins on its surface for about 48 hours, which then quickly decline to zero in a few days. Thus, multiple stringent biochemical conditions and steps must be met to even allow for the tiniest possibility of mRNA vaccine harming the ovaries or other tissues. https://medium.com/microbial-instincts/biodistribution-and-spike-protein-safety-of-mrna-vaccines-an-update-788fe58e39b9 https://medium.com/microbial-instincts/biodistribution-and-s... So I think I'm not supposed to worry about any of this?
- briandon 4y ago
  I'm noticing a lot of "may be" / "consistent with" / etc. language in the lines you're quoting. If I'd received an mRNA covid shot, I might find it very comforting, but there's not much there of substance to grab onto. Quick reactions: * Less than 1% is not zero. Cells that express mod-spike are destroyed. How much autoimmune-mediated cell death in which locations in your or my body would be enough to kick off a chain of events that leads to a discernable real-world injury or death? * Al-Ahmad's statement contrasts strongly with the Japanese Pfizer biodistribution study results: 24.6 + 16.2 = less than half at 48 hours. * I'd love to see the study redone, with a larger number of test animals, at various dosage levels, including human-equivalent. Why did Pfizer use high dosages? Why are high dosages often used in animal studies of new pharmaceutical and other products? * Where are the EU Pfizer biodistribution study results? WIll someone have to leak them or sue Pfizer or the EU to force their disclosure in the same way that Pfizer tried to delay releasing data in tranches over a period of months rather than in 75 years? Come to think of it, why would Pfizer (and the FDA) want to prevent the public from seeing such information for 75 years. Kinda suspicious. * Pfizer has been wrong a lot and many things they said would never happen turn out to happen. Remember that the mRNA has been confirmed in breast milk of recently-vaccinated lactating women. This claim also doesn't match the Japanese Pfizer rodent biodistribution results. * Are the Moderna covid vaccine biodistribution study results public? If so, I'd love to see a link (same for the EU Pfizer biodistribution study). I can't find any sign that such a study was even carried out. In the EMA assessment report from Jan 2021 (https://www.ema.europa.eu/en/documents/assessment-report/spikevax-previously-covid-19-vaccine-moderna-epar-public-assessment-report_en.pdf https://www.ema.europa.eu/en/documents/assessment-report/spi...), they reference a previous rodent biodistribution study conducted by Moderna for mRNA-1647 (which is for CMV aka Cytomegalovirus, not covid) and the sort of detailed breakdown of biodistribution given in the Japanese Pfizer doc isn't included. * Absence of evidence is not evidence of absence. Along with the pronounced spike in all-cause mortality in most nations which saw high penetration of mRNA and adenovirus-vector shots, we've seen a pronounced drop in birthrates. And in some nations, e.g. Scotland, there have been acknowledged increases in neonatal deaths. The authorities there report that the deaths are not due to covid and, without investigating the possibility, not due to maternal vaccination, either (https://www.heraldscotland.com/news/23028843.covid-scotland-vaccines-ruled-cause-neonatal-deaths-spike/ https://www.heraldscotland.com/news/23028843.covid-scotland-...). shrug In England, neonatal deaths are being intentionally misclassified as stillbirths (https://www.telegraph.co.uk/news/2022/10/16/nhs-logging-baby-deaths-stillbirths-avoid-scrutiny/ https://www.telegraph.co.uk/news/2022/10/16/nhs-logging-baby...). Totally coincidentally, English coroners aren't allowed to investigate stillbirths but can investigate neonatal deaths. What's causing the increased all-cause mortality, drop in birth rates, and tip-of-the-iceberg reports of neonatal deaths? Climate change? Negative cerebral emanations? I look forward to observing the evolving scientific consensus on this and other issues. And all for a virus that is a minuscule threat to most healthy people who are not extremely old. And none of these vaccines prevent infection or transmission, so trusting The Science and getting jabbed won't prevent me from getting and spreading it to others. And two-and-done has been discarded, many are on their 5th shot now, and the idea is that this should be at least an annual or perhaps twice-yearly ritual. So I'd be expected to keep getting them and their successors in perpetuity or until I suffered a severe adverse event (like dying in my sleep). It's a tough sell, frankly. I've seen experts and physicians go from lavishing praise on covid vaccines and demanding everyone roll up their arms immediately to acknowledging the importance of bodily autonomy and informed consent and the reality that informed consent is not really possible when individuals are being lied to about both the benefits and the risks. Recently in the news: Kerryn Phelps (a medical doctor, former Australian MP, former head of the Australian Medical Association, current member of OzSAGE, etc.): (https://www.news.com.au/technology/science/human-body/ask-ahpra-dr-kerryn-phelps-doesnt-know-why-regulator-silenced-doctors-on-vaccine-injuries/news-story/a731a655120649f913c8170bfbf1bb96 https://www.news.com.au/technology/science/human-body/ask-ah...)

z7 4y ago

Yeah, but I'm told: >Only <1% of the injected mRNA vaccine got into the ovaries, adrenal glands, heart, brain, and other tissues at 48-hour. >Most of the vaccine remained in the injection site and went into the liver, “suggesting these LNPs may be eliminated mostly via hepatic [liver] clearance route,” Prof. Al-Ahmad wrote. >the dose the Japanese study used is very high when controlled for weight; that is, 18–35-times higher than what is injected into humans. >The Japanese biodistribution study results are consistent with Pfizer’s that was submitted to the European Medicines Agency (EMA) in February 2021. >Pfizer also found that the LNP-encapsulated mRNA vaccine was mainly metabolized in the liver and did not enter other tissues easily. They also noted no effects on fertility or ovarian functions. >For the Moderna mRNA vaccine, the EMA assessment report has previously released its biodistribution data that also finds no cause for concern. And then the author points out the absence of evidence regarding fertility risks: >Even if the mRNA vaccines did enter the ovaries in tiny amounts, there’s no evidence that ovarian cells can translate the mRNA into spike proteins. Even if ovarian cells somehow managed to manufacture some spike proteins, there’s no evidence that this can harm the ovaries. Maybe the spike proteins expressed on ovarian cells degrade within hours or days and disappear in a few days. Animal studies have shown that cells that take up the mRNA vaccine only express the mRNA-encoded proteins on its surface for about 48 hours, which then quickly decline to zero in a few days. Thus, multiple stringent biochemical conditions and steps must be met to even allow for the tiniest possibility of mRNA vaccine harming the ovaries or other tissues. https://medium.com/microbial-instincts/biodistribution-and-spike-protein-safety-of-mrna-vaccines-an-update-788fe58e39b9 https://medium.com/microbial-instincts/biodistribution-and-s... So I think I'm not supposed to worry about any of this?

briandon 4y ago
I'm noticing a lot of "may be" / "consistent with" / etc. language in the lines you're quoting. If I'd received an mRNA covid shot, I might find it very comforting, but there's not much there of substance to grab onto. Quick reactions: * Less than 1% is not zero. Cells that express mod-spike are destroyed. How much autoimmune-mediated cell death in which locations in your or my body would be enough to kick off a chain of events that leads to a discernable real-world injury or death? * Al-Ahmad's statement contrasts strongly with the Japanese Pfizer biodistribution study results: 24.6 + 16.2 = less than half at 48 hours. * I'd love to see the study redone, with a larger number of test animals, at various dosage levels, including human-equivalent. Why did Pfizer use high dosages? Why are high dosages often used in animal studies of new pharmaceutical and other products? * Where are the EU Pfizer biodistribution study results? WIll someone have to leak them or sue Pfizer or the EU to force their disclosure in the same way that Pfizer tried to delay releasing data in tranches over a period of months rather than in 75 years? Come to think of it, why would Pfizer (and the FDA) want to prevent the public from seeing such information for 75 years. Kinda suspicious. * Pfizer has been wrong a lot and many things they said would never happen turn out to happen. Remember that the mRNA has been confirmed in breast milk of recently-vaccinated lactating women. This claim also doesn't match the Japanese Pfizer rodent biodistribution results. * Are the Moderna covid vaccine biodistribution study results public? If so, I'd love to see a link (same for the EU Pfizer biodistribution study). I can't find any sign that such a study was even carried out. In the EMA assessment report from Jan 2021 (https://www.ema.europa.eu/en/documents/assessment-report/spikevax-previously-covid-19-vaccine-moderna-epar-public-assessment-report_en.pdf https://www.ema.europa.eu/en/documents/assessment-report/spi...), they reference a previous rodent biodistribution study conducted by Moderna for mRNA-1647 (which is for CMV aka Cytomegalovirus, not covid) and the sort of detailed breakdown of biodistribution given in the Japanese Pfizer doc isn't included. * Absence of evidence is not evidence of absence. Along with the pronounced spike in all-cause mortality in most nations which saw high penetration of mRNA and adenovirus-vector shots, we've seen a pronounced drop in birthrates. And in some nations, e.g. Scotland, there have been acknowledged increases in neonatal deaths. The authorities there report that the deaths are not due to covid and, without investigating the possibility, not due to maternal vaccination, either (https://www.heraldscotland.com/news/23028843.covid-scotland-vaccines-ruled-cause-neonatal-deaths-spike/ https://www.heraldscotland.com/news/23028843.covid-scotland-...). shrug In England, neonatal deaths are being intentionally misclassified as stillbirths (https://www.telegraph.co.uk/news/2022/10/16/nhs-logging-baby-deaths-stillbirths-avoid-scrutiny/ https://www.telegraph.co.uk/news/2022/10/16/nhs-logging-baby...). Totally coincidentally, English coroners aren't allowed to investigate stillbirths but can investigate neonatal deaths. What's causing the increased all-cause mortality, drop in birth rates, and tip-of-the-iceberg reports of neonatal deaths? Climate change? Negative cerebral emanations? I look forward to observing the evolving scientific consensus on this and other issues. And all for a virus that is a minuscule threat to most healthy people who are not extremely old. And none of these vaccines prevent infection or transmission, so trusting The Science and getting jabbed won't prevent me from getting and spreading it to others. And two-and-done has been discarded, many are on their 5th shot now, and the idea is that this should be at least an annual or perhaps twice-yearly ritual. So I'd be expected to keep getting them and their successors in perpetuity or until I suffered a severe adverse event (like dying in my sleep). It's a tough sell, frankly. I've seen experts and physicians go from lavishing praise on covid vaccines and demanding everyone roll up their arms immediately to acknowledging the importance of bodily autonomy and informed consent and the reality that informed consent is not really possible when individuals are being lied to about both the benefits and the risks. Recently in the news: Kerryn Phelps (a medical doctor, former Australian MP, former head of the Australian Medical Association, current member of OzSAGE, etc.): (https://www.news.com.au/technology/science/human-body/ask-ahpra-dr-kerryn-phelps-doesnt-know-why-regulator-silenced-doctors-on-vaccine-injuries/news-story/a731a655120649f913c8170bfbf1bb96 https://www.news.com.au/technology/science/human-body/ask-ah...)