I have done this for years, specifically because of using Emacs, and now get frustrated now when on a non-mapped keyboard. :) It works out good for CUA bindings

I have done this for years, specifically because of using Emacs, and now get frustrated now when on a non-mapped keyboard. :) It works out good for CUA bindings for other applications also. However, since I am left-handed, the experience might be a little different for me, since I bias towards the left for all modification keys (that includes the Alt key.) The idea of having those keys comfortably near the thumb is interesting though, as some have mentioned, like having a trackpoint so close by when typing (I also remap the top buttons to favor me using my left hand more.)