That hasn't been the case for me, and I've been taking the medications for a while now. I don't drink coffee or any kind of caffeine so I can't compare, but whi

That hasn't been the case for me, and I've been taking the medications for a while now. I don't drink coffee or any kind of caffeine so I can't compare, but while the effect of the medication did reduce slightly after a while, I certainly haven't become noticed tolerance to the extent that the medication doesn't work any more. On the contrary I'm significantly better off since I started taking them. Perhaps some are more susceptible to developing a tolerance?