In people otherwise predisposed, serotonin excess causes anxiety; serotonin depletion causes depression. When depressive symptoms co-occur with serotonin exces

In people otherwise predisposed, serotonin excess causes anxiety; serotonin depletion causes depression. When depressive symptoms co-occur with serotonin excess, antidepressants provide mild symptomatic relief, but trigger a cascade of physiological aging effects. When energetic-anxiety symptoms co-occur with serotonin depletion, SSRIs trigger unpredictable, often aggressive or manic-suicidal behavior.