Lossy causes some issues with normal maps, so QOI seems good for those cases where lossless is preferred to balance loading (and streamed loading) performance a

Lossy causes some issues with normal maps, so QOI seems good for those cases where lossless is preferred to balance loading (and streamed loading) performance and space use, but yes, in general S3TC is good for sRGB color textures in PC games. Using a lossy hardware compression (like S3TC) that's natively supported by the hardware is especially a good way to save on GPU RAM! Double the texture resolution for free, essentially.