5 ms·

Schizophrenia is a degenerative condition where positive symptoms start to be replaced by negative symptoms over the course of years. I've worked in acute adul

Schizophrenia is a degenerative condition where positive symptoms start to be replaced by negative symptoms over the course of years. I've worked in acute adult mental health, and did a few shifts in the long term wards and the difference between people earlier on in the course of their illness versus the end stages are stark.

WhackyIdeas 4y ago
I would so love to chat with someone with your experience. I developed tourettes / ticking a few years ago when I was around 32 and I wonder whether it could be related to the psychosis I once had. When I researched sudden onset ticking I couldn’t really find much about it! There hasn’t been a day in past 4 years I’ve not ticked and it is worse than ever.
- bobkazamakis 4y ago
  https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_spectrum https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_s...
- kotlip 4y ago
  Curious if you've heard about socially-induced Tourette-like behaviours? There was a HN post about it not too long ago, one of the signs was sudden onset later in life: https://news.ycombinator.com/item?id=33878155 https://news.ycombinator.com/item?id=33878155
  - WhackyIdeas 4y ago
    Funny you mention this, because it was only when that story came out that I could even find info about sudden onset Tourette's in people. Mines is the full vocal and movement ticks. But ticks only happen when I get memory flashbacks, which are approximately 50-100 times a day.
psychphysic 4y ago
I'm not fully convinced here, I bet those long term patients were on antipsychotics nearly all of which have extrapyramidal side effects, pretty identical to negative symptoms.
- comfypotato 4y ago
  It’s worth mentioning here that antipsychotics have come a long way since lithium. (Posting from the US with our unfortunate (relative to the developed world) healthcare system.) There’s a handful of antipsychotics and mood stabilizers that have been developed in the last couple of decades that have had unprecedented success with Schizophrenia and Bipolar Disorder. They typically cost $20,000.00 per year before insurance (mine is $0.00 per year after insurance and a coupon, and they get cheap when their patent expires (the patent-clock is 20 years and starts when development starts)). I get to lead a normal life thanks to my medication, and I have experienced no side effects besides the typical mild brainwashing (totally worth it when compared to the alternative). I have friends on other similar newfangled medication, and they have similarly wonderful results. Please forgive the Lisp-ish parentheses. I figure it’s halfway acceptable on HN.
  - niemal_dev 4y ago
    Do you enjoy being on a dopamine antagonist? Are you happy?
  - psychphysic 4y ago
    > Please forgive the Lisp-ish parentheses. I figure it’s halfway acceptable on HN. Haha it did make me wander if there was an Emacs HN client with paren mode. > It’s worth mentioning here that antipsychotics have come a long way since lithium. It's not really related to your comment which is interesting and useful to hear in of its self. But Lithium is not a antipsychotic it's a mood stabiliser and remains to this day a good one. It remains to this day the best evidenced for suicide reduction and intractable depression. Mood stabilizers haven't progressed much (valproate a favoured one is now out for fertile women due to risk of ASD and birth defects). Antipsychotics have shown astounding progress as you say, the reintroduction of clozapine in the 90, introduction of second generations, then Aripiprazole(as a partial D2 agonist was a warning shot we didn't know as much as we thought), quetiapine (made us reassess what a second generation even means as it has even less D2 affinity), pimavanserin (! No D2 but some 5HT-2a activity) And future like SEP-856(!! What the fuck is TAAR1?!). Represent astounding progress. Should SEP-856 get a market authorization it'll turn decades of the dopamine hypothesis fully on its head.

WhackyIdeas 4y ago

I would so love to chat with someone with your experience. I developed tourettes / ticking a few years ago when I was around 32 and I wonder whether it could be related to the psychosis I once had. When I researched sudden onset ticking I couldn’t really find much about it! There hasn’t been a day in past 4 years I’ve not ticked and it is worse than ever.

bobkazamakis 4y ago
https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_spectrum https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_s...
kotlip 4y ago
Curious if you've heard about socially-induced Tourette-like behaviours? There was a HN post about it not too long ago, one of the signs was sudden onset later in life: https://news.ycombinator.com/item?id=33878155 https://news.ycombinator.com/item?id=33878155
- WhackyIdeas 4y ago
  Funny you mention this, because it was only when that story came out that I could even find info about sudden onset Tourette's in people. Mines is the full vocal and movement ticks. But ticks only happen when I get memory flashbacks, which are approximately 50-100 times a day.

psychphysic 4y ago

I'm not fully convinced here, I bet those long term patients were on antipsychotics nearly all of which have extrapyramidal side effects, pretty identical to negative symptoms.

comfypotato 4y ago
It’s worth mentioning here that antipsychotics have come a long way since lithium. (Posting from the US with our unfortunate (relative to the developed world) healthcare system.) There’s a handful of antipsychotics and mood stabilizers that have been developed in the last couple of decades that have had unprecedented success with Schizophrenia and Bipolar Disorder. They typically cost $20,000.00 per year before insurance (mine is $0.00 per year after insurance and a coupon, and they get cheap when their patent expires (the patent-clock is 20 years and starts when development starts)). I get to lead a normal life thanks to my medication, and I have experienced no side effects besides the typical mild brainwashing (totally worth it when compared to the alternative). I have friends on other similar newfangled medication, and they have similarly wonderful results. Please forgive the Lisp-ish parentheses. I figure it’s halfway acceptable on HN.
- niemal_dev 4y ago
  Do you enjoy being on a dopamine antagonist? Are you happy?
- psychphysic 4y ago
  > Please forgive the Lisp-ish parentheses. I figure it’s halfway acceptable on HN. Haha it did make me wander if there was an Emacs HN client with paren mode. > It’s worth mentioning here that antipsychotics have come a long way since lithium. It's not really related to your comment which is interesting and useful to hear in of its self. But Lithium is not a antipsychotic it's a mood stabiliser and remains to this day a good one. It remains to this day the best evidenced for suicide reduction and intractable depression. Mood stabilizers haven't progressed much (valproate a favoured one is now out for fertile women due to risk of ASD and birth defects). Antipsychotics have shown astounding progress as you say, the reintroduction of clozapine in the 90, introduction of second generations, then Aripiprazole(as a partial D2 agonist was a warning shot we didn't know as much as we thought), quetiapine (made us reassess what a second generation even means as it has even less D2 affinity), pimavanserin (! No D2 but some 5HT-2a activity) And future like SEP-856(!! What the fuck is TAAR1?!). Represent astounding progress. Should SEP-856 get a market authorization it'll turn decades of the dopamine hypothesis fully on its head.