3 ms·

Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease R

Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease Result: The mean age was 56 years (SD, 10), and 58% were women. Compared with the HCLF diet, participants on the LCHF diet had greater improvements in hemoglobin A1c (mean difference in change, −6.1 mmol/mol [95% CI, −9.2 to −3.0 mmol/mol] or −0.59% [CI, −0.87% to −0.30%]) and lost more weight (mean difference in change, −3.8 kg [CI, −6.2 to −1.4 kg]). Both groups had higher high-density lipoprotein cholesterol and lower triglycerides at 6 months. Changes in low-density lipoprotein cholesterol were less favorable in the LCHF diet group than in the HCLF diet group (mean difference in change, 0.37 mmol/L [CI, 0.17 to 0.58 mmol/L] or 14.3 mg/dL [CI, 6.6 to 22.4 mg/dL]). No statistically significant between-group changes were detected in the assessment of NAFLD. Changes were not sustained at the 9-month follow-up.

altairprime 4y ago
n=165
chrisco255 4y ago
Meaning the diets were not maintained (on avg) after the trial? Can't imagine how difficult it must be to run a properly controlled dietary study. Even if you feed the participants, how can you be sure they're not ingesting additional food outside of the experiment for months on end?
- AnEro 4y ago
  Exactly why it is normal that nutritional science is taken with a grain of salt, not cause researchers are slacking or producing bad studies. Just the fact they have data sources with a giant astrix attached. Imho i think this also plays into the misinformation in the space. It's hard to prove anything and I find I mostly wait for a good meta analysis before putting my eggs in that basket
  - BLKNSLVR 4y ago
    Aside: "astrix"? If intended to be funny, it certainly is. If not, I believe "asterisk" is the word you're looking for. However, I could see astrix becoming the word of 2023. Related: https://www.asterix.com https://www.asterix.com
- chasebank 4y ago
  Why not run these trials in a prison?
  - chrisco255 4y ago
    Ha, probably ethics reasons. Plus prisons aren't representative of general population.
- cableshaft 4y ago
  I did a Keto diet for 4 months and lost 45lbs. Those pounds started coming back quick after I eased off of it (my triglycerides and cholesterol numbers were getting worryingly high). I also found it incredibly difficult to jump back into Keto for any sustained period of time afterwards. Tried and failed within a couple of weeks multiple times, kind of like whenever I try to go off of caffeine. Been finding just eating lower-carb (not as low as keto, and some days where there have been carb binges) and focusing more on whole foods and not eating high-fat foods and my triglycerides and cholesterol numbers are back to normal levels, and I'm back to losing weight again, albeit a lot slower (down 25 lbs this year). I know another guy who lost 107lbs off Keto (he was my initial inspiration to try it, in fact) and he eventually went off it and he had regained about half of that when I saw him last (according to him). I'm sure there are people who have been able to keep the weight off, but it was difficult for me.

altairprime 4y ago

n=165

chrisco255 4y ago

Meaning the diets were not maintained (on avg) after the trial? Can't imagine how difficult it must be to run a properly controlled dietary study. Even if you feed the participants, how can you be sure they're not ingesting additional food outside of the experiment for months on end?

AnEro 4y ago
Exactly why it is normal that nutritional science is taken with a grain of salt, not cause researchers are slacking or producing bad studies. Just the fact they have data sources with a giant astrix attached. Imho i think this also plays into the misinformation in the space. It's hard to prove anything and I find I mostly wait for a good meta analysis before putting my eggs in that basket
- BLKNSLVR 4y ago
  Aside: "astrix"? If intended to be funny, it certainly is. If not, I believe "asterisk" is the word you're looking for. However, I could see astrix becoming the word of 2023. Related: https://www.asterix.com https://www.asterix.com
chasebank 4y ago
Why not run these trials in a prison?
- chrisco255 4y ago
  Ha, probably ethics reasons. Plus prisons aren't representative of general population.
cableshaft 4y ago
I did a Keto diet for 4 months and lost 45lbs. Those pounds started coming back quick after I eased off of it (my triglycerides and cholesterol numbers were getting worryingly high). I also found it incredibly difficult to jump back into Keto for any sustained period of time afterwards. Tried and failed within a couple of weeks multiple times, kind of like whenever I try to go off of caffeine. Been finding just eating lower-carb (not as low as keto, and some days where there have been carb binges) and focusing more on whole foods and not eating high-fat foods and my triglycerides and cholesterol numbers are back to normal levels, and I'm back to losing weight again, albeit a lot slower (down 25 lbs this year). I know another guy who lost 107lbs off Keto (he was my initial inspiration to try it, in fact) and he eventually went off it and he had regained about half of that when I saw him last (according to him). I'm sure there are people who have been able to keep the weight off, but it was difficult for me.