> What happens when it turns out some genetic inserts in the corn creates something like mad cow disease (but in humans) 3-5 years later? Turns out some protein

> What happens when it turns out some genetic inserts in the corn creates something like mad cow disease (but in humans) 3-5 years later? Turns out some protein the corn produced we thought was harmless caused massive issues. Do you require similar safeguards with plants created by "classic" genetic engineering and random mutations occurring all the time? Such methods usually involve making tons of random mutations, which nobody tests for anything, until we manage to also get the one that we want. Of course you rarely make a completely new protein by random mutations (different story with naturally evolving viruses), however, current genetic engineering of plants and animals for food is AFAIK not about completely new proteins too -- it's about turning off existing pathways, or about transferring existing proteins from one species to another.