4 ms·
Do people with base-edited DNA pass their modified genes on to their offspring?
by beaned 4y ago
Do people with base-edited DNA pass their modified genes on to their offspring?
- elektrontamer 4y agoGerm cells need to be edited for that. The edited T cells can't get inherited.
- gizmo686 4y agoNo. The only DNA that gets passed to offspring is what is in the sperm/eggs. Collectively these are referred to as the "germline". Research into germline editing is illegal in the US, and frowned upon internationally. The most famous case is from 2018, when Chinese researcher He Jiankui created the first genome-edited babies. Using CRISPR to give the babies resistance to HIV-1. [0]. This change will propagate to the decedents of the subjects [1]. The Chinese Academy of Science, along with the global medical community, denounced this experiment; and He Jiankui was arrested. [0] The necessary mutation, while rare in humans, is naturally occurring, and generally thought to confer HIV-1 resistance. [1] Subject to normal genetics that arrises from sexual reproduction, where a given parent is responsible for only half of a child's genes.
- NaturalPhallacy 4y ago>Research into germline editing is illegal in the US, and frowned upon internationally. I would bet money someone's doing it anyway.
- mr_toad 4y agoThere seems to be more money in not doing it. Why sell something permanent, when you can sell the treatment again and again to each generation? So if we want to start getting cynical we could suppose that there are shadowy forces trying to prevent the development of this technology.