3 ms·
The article states “The first base edit disabled the T-cells targeting mechanism so they would not assault Alyssa's body”. Not an expert but I presume the ‘targ
by frontierkodiak 4y ago
The article states “The first base edit disabled the T-cells targeting mechanism so they would not assault Alyssa's body”. Not an expert but I presume the ‘targeting mechanism’ is the T-cell receptor, whose activation is necessary (but not sufficient) to trigger immune response.
- hooloovoo_zoo 4y agoMaybe, but the second transplant also needs to not assault Alyssa.
- Narretz 4y agoThe second transplant is a stem cell (bone marrow) transplant, i.e. it replaces the cells that produce the t-cells. This is how leukemia therapy is normally finished after chemotherapy / radiation therapy kills the cancer cells.