3 ms·
Great to see medical techniques slowly starting to resemble engineering design: 1. Donor T-cells added with receptors to destroy the recipient's cancerous T-ce
by hliyan 4y ago
Great to see medical techniques slowly starting to resemble engineering design:
1. Donor T-cells added with receptors to destroy the recipient's cancerous T-cells.
2. Donor T-cells' markers removed to prevent them from attacking each other.
3. Donor T-cells' existing receptors removed to prevent them from attacking the recipient's other cells (since the donor T-cell will see them as 'foreign').
4. Donor T-cells altered to resist chemotherapy.
It seems each of these changes were achieved by editing specific base pairs to break the relevant gene, except perhaps for (1)
- adamredwoods 4y agoTo even have something like this actually respond, in the way they planned it, is a marvel. I know they have worked with T-Cells before, but this is putting it to precise use. Sadly, cancer is vicious. It only takes one rogue cell to keep building, about 2-years for it to surface again. Luckily, this process seems repeatable. I can't imagine the euphoria that family feels right now.
- psychphysic 4y agoIt sounds like they continued chemo. T-cells immune from the chemo targeting cancerous T-cells during the chemo treatment is pretty potent.