3 ms·

I think if we had ways to transplant, repair, and/or supplant mitochondria, we might be able to restore function at an organelle level as opposed to MRT one-sho

I think if we had ways to transplant, repair, and/or supplant mitochondria, we might be able to restore function at an organelle level as opposed to MRT one-shot in vitro prior to gestation.

maxerickson 4y ago
There's a corner case where it is starting to happen. Women with mitochondrial disorders will pass them on to any children they have. Mitochondrial replacement therapy during IVF swaps most of the mitochondria with those from a donor. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492815/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492815/