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Bike rallies are generally large, crowded events that take place in rural areas or small towns with traffic infrastructure intended for much smaller populations

Bike rallies are generally large, crowded events that take place in rural areas or small towns with traffic infrastructure intended for much smaller populations and far less traffic, the researchers noted... The seven motorcycle rallies in the study each draw more than 200,000 visitors over the course of several days. Hardly surprising to me. I paid accident claims for a few years. One vehicle, low speed car crash and people wanted us to pay their physical therapy/chiro treatments. One vehicle, low speed motorcycle crash and people wanted us to pay their surgery. I will note once again that I wish we would do more to find other answers. Organ donation gets called "the gift of life" but some people reject the donated organs and die slowly and gruesomely over a period of weeks. If they don't reject them, it's crazy expensive, very hard on the body and you will be on anti-rejection drugs the rest of your life. I'm not against saving lives and giving people a second chance. I just think this is a procedure that gets a lot of hype and it takes away from us pursuing something that might be better overall but just can't compete in the click-bait headline department.

waterhouse 4y ago
> I just think this is a procedure that gets a lot of hype and it takes away from us pursuing something that might be better overall Growing organs from your DNA seems like the thing that would clearly work, if it could be done. Seems people are working on it. Some google results talk about growing those organs in genetically-modified pigs (!). Don't know how far away it is.
- DoreenMichele 4y ago
  That's not at all the kind of alternative I have in mind and would be of essentially zero use in cases of organ transplant for people with genetic disorders. (Edit: For example, cystic fibrosis accounted for a third of all adult lung transplants in the US and half of all pediatric lung transplants last I checked.)
  - waterhouse 4y ago
    Would it really? If you're doing genetic engineering already and you know what the genetic disorder is, it seems like you could then engineer a version of your DNA without the disorder and grow an organ from that.
    - DoreenMichele 4y ago
      It would, by definition, at that point no longer be identical to your DNA. I have no idea if at that point you risk rejection, etc.
      - pkaye 4y ago
        I think if the new DNA kept the DNA encoding for the HLA markers there wouldn't be any rejection risk. HLA markers allow the immune system to tell which cells belong to your own body. When they do transplants, they check for HLA compatibility much as possible.
      - andrewflnr 4y ago
        In my understanding, rejection is mostly due to things like cell surface proteins. It looks like cystic fibrosis is in fact a mutation in a surface protein, but at least it's only one. I'm guessing that's manageable...
- 1letterunixname 4y ago
  Ideally, your umbilical cord should be frozen at birth, a non-IPSC line of stem cells created and frozen ready to restore you, and your full genome sequenced. In the distant future, people will have spare organs ready should they be gravely injured.
krisoft 4y ago
> I just think this is a procedure that gets a lot of hype and it takes away from us pursuing something that might be better overall but just can't compete in the click-bait headline department. What does it take away? It is a procedure of last resort. Doctors don’t plop in new major organs willy nilly. If there is any chance to fix what is wrong with the patient through other means they try that. There is much more energy spent on protecting peoples organs (the ones they were born with) than on replacing organs. As it should be. It is just when a doctor swaps a medication or lowers a dose to prevent kidney or liver injury that doesn’t sound as dramatic and attention grabbing as a huge life saving operation. Even in the “headline grabbing” department lab grown organs are much more catchy and futuristic.
- DoreenMichele 4y ago
  There is much more energy spent on protecting peoples organs (the ones they were born with) than on replacing organs. That's the narrative the world would like to believe for various reasons, but it doesn't fit my firsthand experience at all.
  - dmitriid 4y ago
    Any stats on "organ transplants vs. literally every other treatment" invalidate your "firsthand experience". I'd bet that even in your "firsthand experience", however skewed it is, treatment was significantly more prevalent than organ transplants. There are in total just over 40 000 organ transplants in all of US. [1] Do you really want to tell us that there are fewer than 40 thousand attempts to save/protect a person's own organs? [1] https://optn.transplant.hrsa.gov/news/all-time-records-again-set-in-2021-for-organ-transplants-organ-donation-from-deceased-donors/ https://optn.transplant.hrsa.gov/news/all-time-records-again...
    - DoreenMichele 4y ago
      Any stats on "organ transplants vs. literally every other treatment" invalidate your "firsthand experience". No, they don't. But I'm very well aware that no one actually cares to hear my point of view. That's not at all news.
SuoDuanDao 4y ago
The downvoting of your thoughtful (but minority opinion) post is evidence of the hype you mention. I think it's part of the postmodern rationalist ersatz religion that still holds a lot of sway on the internet to affect a disattachment from one's own body parts in the event of death.

waterhouse 4y ago

> I just think this is a procedure that gets a lot of hype and it takes away from us pursuing something that might be better overall Growing organs from your DNA seems like the thing that would clearly work, if it could be done. Seems people are working on it. Some google results talk about growing those organs in genetically-modified pigs (!). Don't know how far away it is.

DoreenMichele 4y ago
That's not at all the kind of alternative I have in mind and would be of essentially zero use in cases of organ transplant for people with genetic disorders. (Edit: For example, cystic fibrosis accounted for a third of all adult lung transplants in the US and half of all pediatric lung transplants last I checked.)
- waterhouse 4y ago
  Would it really? If you're doing genetic engineering already and you know what the genetic disorder is, it seems like you could then engineer a version of your DNA without the disorder and grow an organ from that.
  - DoreenMichele 4y ago
    It would, by definition, at that point no longer be identical to your DNA. I have no idea if at that point you risk rejection, etc.
    - pkaye 4y ago
      I think if the new DNA kept the DNA encoding for the HLA markers there wouldn't be any rejection risk. HLA markers allow the immune system to tell which cells belong to your own body. When they do transplants, they check for HLA compatibility much as possible.
    - andrewflnr 4y ago
      In my understanding, rejection is mostly due to things like cell surface proteins. It looks like cystic fibrosis is in fact a mutation in a surface protein, but at least it's only one. I'm guessing that's manageable...
1letterunixname 4y ago
Ideally, your umbilical cord should be frozen at birth, a non-IPSC line of stem cells created and frozen ready to restore you, and your full genome sequenced. In the distant future, people will have spare organs ready should they be gravely injured.

krisoft 4y ago

> I just think this is a procedure that gets a lot of hype and it takes away from us pursuing something that might be better overall but just can't compete in the click-bait headline department. What does it take away? It is a procedure of last resort. Doctors don’t plop in new major organs willy nilly. If there is any chance to fix what is wrong with the patient through other means they try that. There is much more energy spent on protecting peoples organs (the ones they were born with) than on replacing organs. As it should be. It is just when a doctor swaps a medication or lowers a dose to prevent kidney or liver injury that doesn’t sound as dramatic and attention grabbing as a huge life saving operation. Even in the “headline grabbing” department lab grown organs are much more catchy and futuristic.

DoreenMichele 4y ago
There is much more energy spent on protecting peoples organs (the ones they were born with) than on replacing organs. That's the narrative the world would like to believe for various reasons, but it doesn't fit my firsthand experience at all.
- dmitriid 4y ago
  Any stats on "organ transplants vs. literally every other treatment" invalidate your "firsthand experience". I'd bet that even in your "firsthand experience", however skewed it is, treatment was significantly more prevalent than organ transplants. There are in total just over 40 000 organ transplants in all of US. [1] Do you really want to tell us that there are fewer than 40 thousand attempts to save/protect a person's own organs? [1] https://optn.transplant.hrsa.gov/news/all-time-records-again-set-in-2021-for-organ-transplants-organ-donation-from-deceased-donors/ https://optn.transplant.hrsa.gov/news/all-time-records-again...
  - DoreenMichele 4y ago
    Any stats on "organ transplants vs. literally every other treatment" invalidate your "firsthand experience". No, they don't. But I'm very well aware that no one actually cares to hear my point of view. That's not at all news.

SuoDuanDao 4y ago

The downvoting of your thoughtful (but minority opinion) post is evidence of the hype you mention. I think it's part of the postmodern rationalist ersatz religion that still holds a lot of sway on the internet to affect a disattachment from one's own body parts in the event of death.