It really depends on your level of commitment to getting the infotainment out of the vehicle. Most cars will have the infotainment in a CAN or flexray network

It really depends on your level of commitment to getting the infotainment out of the vehicle. Most cars will have the infotainment in a CAN or flexray network with a bunch of other stuff in the cockpit. Theoretically unless other systems are tightly integrating with the infotainment (using their GPS localization data for example) you could theoretical just snif the network through your OBD connector and find out what messages your infotainment sends (i.e. whatever messages dissapear when you power the infotainment off). Most of the time the Body Control Module (the master of ceremonies in the cockpit) is just checking that a particular range of message IDs are being sent to 'assume' that the infotainment is 'online'. So sending those messages on the OBD port as a man-in-the-middle of sorts would theoretically keep all the other systems happy. So I suppose it really depends on how far you are willing to go. Also I think it would be difficult to make the trim look any good after removing the central infotainment system.