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>participants were randomized to consume high-dose GTE (843 mg/day EGCG) or placebo capsules for 12 months. How much green tea would you have to drink to get t

>participants were randomized to consume high-dose GTE (843 mg/day EGCG) or placebo capsules for 12 months. How much green tea would you have to drink to get that much absent doing weird supplements?

dwpk 4y ago
Cerium 4y ago
Based on this paper [1] green tea can have up to about 130 mg per gram EGCG. In that case 6.5 grams of tea. Tea bags usually have about a gram and a half, but the extracion is less. In studies like this the tea is usually brewed for 5 minutes and in this study brewed 1g to 100ml. My take is that it is not an unreasonable amount. [1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100455/#!po=31.6092 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100455/#!po=31...
- gumby 4y ago
  That's quite interesting. I assumed that tea drinkers would be fine but people who take a supplement could poison themselves. But I easily drink at least a half a dozen cups of tea in a day, so could approach this dose.
jamesredd 4y ago
Drinking green tea doesn't seem to produce the same hepatoxicity as seen with green tea extract taken in pill form. The problem is the high catechin concentration of the extract and the large acute dose. https://pubmed.ncbi.nlm.nih.gov/29580974/ https://pubmed.ncbi.nlm.nih.gov/29580974/ "Average green tea consumption was reportedly three cups per day among tea drinkers (Hakim et al., 2003; Kaegi, 1998; Khokhar and Magnusdottir, 2002), while in some countries it could be as high as ten cups per day (Muramatsu, 1991)" "Our review supports that consumption of GTE or EGCG in bolus dose, but not green tea consumed as a beverage or part of the diet, is causally associated with hepatotoxicity" "Evidence from animal studies demonstrated that hepatotoxicity risk rose with increasing concentrations of catechins and EGCG" "Hepatotoxicity was clearly absent in the animal studies in which GTE or EGCG was administered in the diet or drinking water despite that concentrations of catechins in the test materials were greater than that of a traditional green tea infusion (> 68% w/w)."
- FollowingTheDao 4y ago
  Yes, catechin is my enemy. It inhibits the Nitric Oxide Synthase Enzyme as well and that messes me up mentally. https://www.sciencedirect.com/science/article/abs/pii/S0304394012000171 https://www.sciencedirect.com/science/article/abs/pii/S03043... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303682/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303682/

>participants were randomized to consume high-dose GTE (843 mg/day EGCG) or placebo capsules for 12 months. How much green tea would you have to drink to get that much absent doing weird supplements?

dwpk 4y ago

Cerium 4y ago

Based on this paper [1] green tea can have up to about 130 mg per gram EGCG. In that case 6.5 grams of tea. Tea bags usually have about a gram and a half, but the extracion is less. In studies like this the tea is usually brewed for 5 minutes and in this study brewed 1g to 100ml. My take is that it is not an unreasonable amount. [1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100455/#!po=31.6092 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100455/#!po=31...

gumby 4y ago
That's quite interesting. I assumed that tea drinkers would be fine but people who take a supplement could poison themselves. But I easily drink at least a half a dozen cups of tea in a day, so could approach this dose.

jamesredd 4y ago

Drinking green tea doesn't seem to produce the same hepatoxicity as seen with green tea extract taken in pill form. The problem is the high catechin concentration of the extract and the large acute dose. https://pubmed.ncbi.nlm.nih.gov/29580974/ https://pubmed.ncbi.nlm.nih.gov/29580974/ "Average green tea consumption was reportedly three cups per day among tea drinkers (Hakim et al., 2003; Kaegi, 1998; Khokhar and Magnusdottir, 2002), while in some countries it could be as high as ten cups per day (Muramatsu, 1991)" "Our review supports that consumption of GTE or EGCG in bolus dose, but not green tea consumed as a beverage or part of the diet, is causally associated with hepatotoxicity" "Evidence from animal studies demonstrated that hepatotoxicity risk rose with increasing concentrations of catechins and EGCG" "Hepatotoxicity was clearly absent in the animal studies in which GTE or EGCG was administered in the diet or drinking water despite that concentrations of catechins in the test materials were greater than that of a traditional green tea infusion (> 68% w/w)."

FollowingTheDao 4y ago
Yes, catechin is my enemy. It inhibits the Nitric Oxide Synthase Enzyme as well and that messes me up mentally. https://www.sciencedirect.com/science/article/abs/pii/S0304394012000171 https://www.sciencedirect.com/science/article/abs/pii/S03043... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303682/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303682/