3 ms·
There are a lot of different reasons why someone can have long covid. But a common one is that the person's immune system still appears to be inflamed / hypera
by ep103 4y ago
There are a lot of different reasons why someone can have long covid. But a common one is that the person's immune system still appears to be inflamed / hyperactive long after the initial infection is over. Or at least, the immune system is still active enough that it is putting enough of a tax on the body, that the body is unable to restore back to normal levels in the recovery time after fighting off the infection.
This is pretty undisputed as a very common occurrence among long covid victims after the infection. There is a lot of debate on whether or not this is sufficient as a metric to identify long covid, because there are lots of reasons why someone could have long covid, this is just a particularly common one. There is even more controversy on why this is happening (the fact that it is happening is not controversial), because the common belief is that once the body fights off the virus, the immune system should naturally calm down again, which, obviously, isn't the case for many patients.
There have been some studies that show that LC victims sometimes have sustained enough damage that the immune system is still raised as a result of that damage. There have been some studies that show that some LC victims still actively have the virus in their system, which could be responsible. And that's before you even start wondering about things like other complications, or the degree to which people may be getting reexposed on a regular basis. Etc.
Glucocorticoid steroids (of which prednisone is among the most common) suppress your immune system. Specifically, it suppresses cytokines IL-1,6, and 10, and the gamma one (sorry, I'm not a doctor). For a _lot_ of people, this seems to finally calm their immune system down, give the body a breather to restore back to normal, and _many_ patients stay better after the treatment.
Many Asthma medications have a similar cytokine effect, and users & doctors colloquially report positives there too.
Among the LC community, the supplements that are most touted seem to generally align with having effects on the same systems that are much more effectively targeted by a glucocorticoid steroid.
But again, LC can be for many reasons, studies are still inconclusive, and western science is awful at treating chronic conditions particularly when they're complicated by other underlying conditions, so fingers crossed and good luck.
That said, prednisone gave me my life back, so I would strongly recommend it if your symptoms line up with any of the raised cytokine / histamine symptoms. I could provide some documentation I've found about that if it helps.
- AnimalMuppet 4y agoThat's very informative. Thank you.