4 ms·
Alzheimer's drug lecanemab hailed as momentous breakthrough; targets root cause
- kalimanzaro 4y agoNot in the BBC article: "Second death linked to potential antibody treatment for Alzheimer’s disease Woman’s brain hemorrhage while receiving Eisai’s widely heralded lecanemab heightens concerns overs its safety 27 NOV 2022•8:00 PM•Science "Rudolph Castellani, a Northwestern neuropathologist who studies Alzheimer’s and conducted an autopsy at the request of the patient’s husband, called the case “very dramatic.” The report, co-authored by Castellani, concluded that the woman, like the other person whose death was linked to lecanemab..", https://archive.ph/FkYss https://archive.ph/FkYss https://archive.ph/nye78 https://archive.ph/nye78
- dkural 4y agoIt's far from clear that this is the "root cause". There is a good chance any therapeutic effect goes away after larger trials, like every single other drug targeting the same mechanism so far.
- elischleifer 4y agoThis disease is just absolutely devastating; I remember reading over the past couple years how the connection between protein buildup and alzheimers was being questioned more in the research. When a momentous breakthrough is a 25% delay in symptoms - you know things are bad.
- klooney 4y agoAnd no mention of the fight over the amyloid hypothesis