4 ms·
Sensation is not perception. To be psychoactive, capsaicin would need to warp your perceptions, rather than solely induce the sensation of burning pain.
by 9wzYQbTYsAIc 4y ago
Sensation is not perception.
To be psychoactive, capsaicin would need to warp your perceptions, rather than solely induce the sensation of burning pain.
- voxic11 4y agoAs the original article notes it does appear to have a psychoactive effect beyond the sensation of burning pain (though if a sensation of pleasure is a psychoactive effect why wouldn't a sensation of pain be?). I found additional sources going into the likely pharmacology of this effect: > Namely, capsaicin and vanillin (and anandamide itself) are all agonists of the TRPV1 receptor, which stimulates production and release of endogenous anandamide. When mixed with N-linoleoylethanolamide and N-oleoylethanolamide from cacao, which inhibit anandamide breakdown, the levels of endogenous anandamide are augmented further. When breakdown of anandamide is inhibited pharmacologically or genetically, anandamide is able to produce a state of intoxication similar to tetrahydrocannabinol in rodents and nonhuman primates https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706955/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706955/
- 9wzYQbTYsAIc 4y agoInteresting, that does remind me of times that some people would experience a brief “glow” feeling after consuming a handful of “inferno” chicken wings.