3 ms·
>basically the vaccines only present one antigen whereas in natural infection there are multiple antigens. Once the immune system learns one it generally doesn’
by KVFinn 4y ago
>basically the vaccines only present one antigen whereas in natural infection there are multiple antigens. Once the immune system learns one it generally doesn’t learn more on the next exposure (actual infection)
Surprising, it looks like this isn't really a problem. The immune system manages to adapt to handle a greater variety of strains, if you give it long time between boosters/exposures, so memory B cells can mature.
https://www.nature.com/articles/d41586-022-03119-3 https://www.nature.com/articles/d41586-022-03119-3
- jtc331 4y agoI don’t think that link addresses the concern directly: it’s saying that the B cells can recognize multiple variant’s spike antigen, but the data shows that only ~10% of people vaccinated prior to natural infection developed N protein antibodies while almost all people who have natural infection first develop both S and N protein antibodies.