4 ms·

Isn’t this obvious?

yjftsjthsd-h 4y ago
Why would it be obvious? For that matter, since I'm out of the loop, what's the mechanism for losing fat to improve insulin control?
- chasebank 4y ago
  I thought this was common knowledge. Type 2 diabetes is 100% reversible through diet.
  - Retric 4y ago
    Early Type 2 is generally reversible through diet, but untreated you can suffer irreversible harm.
    - wrycoder 4y ago
      This is correct. Further, I don't know what it has to do with race - all humans respond to low calorie diets in the same way. There is the case of lactic intolerance due to loss of a particular gene. I'm not aware of any similar gene being involved in insulin intolerance.
  - wrycoder 4y ago
    Yes, I should have put it that way. Thanks.
- oaktrout 4y ago
  Simply put fat worsens insulin resistance. The mechanism is complex, basically fat causes inflammation that causes cells to not respond appropriately to insulin. This leads to elevated blood glucose and all the effects of diabetes. Remove the fat, decrease inflammation, improve insulin resistance.
JPLeRouzic 4y ago
> Isn’t this obvious? Please consider wondering why no doctors/scientist know how to heal people with diabetes. Do they miss something obvious?
- oaktrout 4y ago
  Most doctors know how to heal people with type 2 diabetes, at least if you catch it early enough. It is well known that if you lose weight and eat a healthy diet the insulin resistance is reversible (some others in this thread have provided citations showing this).
- Vt71fcAqt7 4y ago
  While not exactly obvious, this has been known for a while now. It even became the position statement of the American College of Lifestyle Medicine to restrict calories as a way to induce remission: >Studies with therapeutic dosing typically used very low energy diets (600-1100 kcal/day) with a weighted mean remission rate of 49.4%, while studies with subtherapeutic dosing typically used more moderate caloric restrictions (reducing energy intake by 500-600 kcal/day) and the weighted mean remission rate was 6.9%. Conclusions. Remission should be the clinical goal in T2D treatment, using properly dosed intensive lifestyle interventions as a primary component of medical care for T2D patients.[0] So while not exactly obvious, it isn't true that "no doctors/scientist know how to heal people with diabetes." The real issue is that people with DMT2 generaly will not accept low calorie diets. But those that do have a high rate of remission and almost all have improved symptoms and decreased progressions. Edit: I should note that obviously the American College of Lifestyle Medicine would advocate for this. My point is that there is sufficient liturature to back this up. [0]Type 2 Diabetes Remission and Lifestyle Medicine: A Position Statement From the American College of Lifestyle Medicine (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692017/?report=reader https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692017/?report...
  - PuppyTailWags 4y ago
    Wait, how long are people expected to be on 600-1100 kcal/day? Just for a little worse than a coin flip? That sounds really miserable. Isn't that basically a crash diet and no one stfus about not doing those because they can mess you up long term? I'm really confused how T2D are special such that crash dieting doesn't mess them up further and put them further in a hole. They're already messed up because of the T2D, aren't they?

Isn’t this obvious?

Why would it be obvious? For that matter, since I'm out of the loop, what's the mechanism for losing fat to improve insulin control?

chasebank 4y ago
I thought this was common knowledge. Type 2 diabetes is 100% reversible through diet.
- Retric 4y ago
  Early Type 2 is generally reversible through diet, but untreated you can suffer irreversible harm.
  - wrycoder 4y ago
    This is correct. Further, I don't know what it has to do with race - all humans respond to low calorie diets in the same way. There is the case of lactic intolerance due to loss of a particular gene. I'm not aware of any similar gene being involved in insulin intolerance.
- wrycoder 4y ago
  Yes, I should have put it that way. Thanks.
oaktrout 4y ago
Simply put fat worsens insulin resistance. The mechanism is complex, basically fat causes inflammation that causes cells to not respond appropriately to insulin. This leads to elevated blood glucose and all the effects of diabetes. Remove the fat, decrease inflammation, improve insulin resistance.

JPLeRouzic 4y ago

> Isn’t this obvious? Please consider wondering why no doctors/scientist know how to heal people with diabetes. Do they miss something obvious?

oaktrout 4y ago
Most doctors know how to heal people with type 2 diabetes, at least if you catch it early enough. It is well known that if you lose weight and eat a healthy diet the insulin resistance is reversible (some others in this thread have provided citations showing this).
Vt71fcAqt7 4y ago
While not exactly obvious, this has been known for a while now. It even became the position statement of the American College of Lifestyle Medicine to restrict calories as a way to induce remission: >Studies with therapeutic dosing typically used very low energy diets (600-1100 kcal/day) with a weighted mean remission rate of 49.4%, while studies with subtherapeutic dosing typically used more moderate caloric restrictions (reducing energy intake by 500-600 kcal/day) and the weighted mean remission rate was 6.9%. Conclusions. Remission should be the clinical goal in T2D treatment, using properly dosed intensive lifestyle interventions as a primary component of medical care for T2D patients.[0] So while not exactly obvious, it isn't true that "no doctors/scientist know how to heal people with diabetes." The real issue is that people with DMT2 generaly will not accept low calorie diets. But those that do have a high rate of remission and almost all have improved symptoms and decreased progressions. Edit: I should note that obviously the American College of Lifestyle Medicine would advocate for this. My point is that there is sufficient liturature to back this up. [0]Type 2 Diabetes Remission and Lifestyle Medicine: A Position Statement From the American College of Lifestyle Medicine (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692017/?report=reader https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692017/?report...
- PuppyTailWags 4y ago
  Wait, how long are people expected to be on 600-1100 kcal/day? Just for a little worse than a coin flip? That sounds really miserable. Isn't that basically a crash diet and no one stfus about not doing those because they can mess you up long term? I'm really confused how T2D are special such that crash dieting doesn't mess them up further and put them further in a hole. They're already messed up because of the T2D, aren't they?