Great post - which contains the answer to many of the questions raised in this thread. I am working in this area as well. There is "next to zero demand for tool

Great post - which contains the answer to many of the questions raised in this thread. I am working in this area as well. There is "next to zero demand for tool development" because there are great open source tools. Only in rare cases (e.g. Illumina Dragen), a commercial software adds significant value that the audience is willing to pay for.