3 ms·
That is an interesting paper, as is the co-morbidity of ADHD with epilepsy that they cite. It's also hopeful for some people suffering from ADHD because it is s
by mtsr 4y ago
That is an interesting paper, as is the co-morbidity of ADHD with epilepsy that they cite. It's also hopeful for some people suffering from ADHD because it is suggestive of the possibility of a more complete treatment for some.
However there's a general understanding of ADHD (and related disorders such as ASD) as a spectrum of conditions with multiple contributing factors. Depending on the person ADHD will manifest with more or less hyperactivity, distractability, working memory issues, and lacking emotional regulation (among other things). Different causes combine to give a somewhat amorphous disorder with a range of common symptoms.
So adding a new treatment with fewer downsides (because stimulants can have a few) is great, especially as it might treat aspects of the disorder that aren't treated by stimulants. But this doesn't mean stimulants won't still be relevant in the future.
There's there's also plenty of research showing specific dopamine receptor dysregulations as contributing to ADHD. See for example https://www.researchgate.net/publication/364120700_Dopamine_Receptor_Expression_and_the_Pathogenesis_of_Attention-Deficit_Hyperactivity_Disorder_a_Scoping_Review_of_the_Literature https://www.researchgate.net/publication/364120700_Dopamine_...
So unless the research also shows that this is caused by pyridoxine metabolism problems, these hypotheses can both hold at the same time.
Picking some paper that talks about different causes doesn't mean other causes aren't still relevant. It will probably be decades before we can definitively rule out contributing factors.
PS It's generalizations like yours that are very stigmatizing towards stimulant use. We already know many people benefit from them enormously and significant numbers are not getting or taking them due to stigma.
- FollowingTheDao 4y agoYou are making a complicated when it’s effing simple. Just try taking high dose P5P. And probably zinc: https://www.nature.com/articles/s41598-021-94124-5 https://www.nature.com/articles/s41598-021-94124-5 If you knew the metabolic pathways thus would be as clear as day. We need enzymes to make neurotransmitter and those enzymes need cofactors to work. These are the cofactors.
- mtsr 4y agoIf only things were generally so simple. While I'm all for more possible causes that are more easily treated, I’d hardly call this convincing evidence that all we need to treat is zinc deficiencies. But time will tell, as I hope these kinds of research continue.
- FollowingTheDao 4y agoBut did you try it????
- Jensson 4y agoYes, didn't work, stop acting like an asshole. It is very common to check for deficiencies, if people with ADHD had it then likely they wouldn't be prescribed meds before the deficiency is fixed in the first place, you questioning others like this is just making their life worse.
- FollowingTheDao 4y agoOne, I do not beleive you. Two, If you did, how much did you take? And what type? Pyridoxine or Pyridoxal-Phosphate? For how long? Were you tested for a B6 defieicny, high homocysteine? Three, it is in NO WAY common for deficiencies to be tested for mood disorders and even less common for a doctor nevermind a psychiatrist to do anything about it. And calling me an asshole when I am advocating for better health is making everyone's life worse. I do not mind if people choose to take stimulants, but they are not being advised that there are other options.
- Jensson 4y ago> One, I do not beleive you. That makes you an asshole. > Three, it is in NO WAY common for deficiencies to be tested for mood disorders and even less common for a doctor nevermind a psychiatrist to do anything about it. Why do you believe this? It is easy and cheap to do a blood test for deficiencies, I have done that many time and they found I lacked nothing. Do you have any evidence it isn't common to check for deficiencies, because to me it seems like that is one of the first thing they check.