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Are you not aware that dopamine receptor density increases over time with amphetamine use? Amphetamine may be a net positive for some folks despite this, but fo
by sedivy94 4y ago
Are you not aware that dopamine receptor density increases over time with amphetamine use? Amphetamine may be a net positive for some folks despite this, but for others it actually exacerbates the condition over time.
- mtsr 4y agoI think it’s a decrease of receptors or an increase of re-uptake. But yes, there have been results pointing in that direction, but as far as I’m aware this is not as clear as that. Who does it affect? Is it seen with abusers or with users of (generally much lower dosed) meds? How much? How does this compare to the dopamine deficiency we see without treatment? Etc. But if you have a good and recent source, I’d love to read it.
- dr_dshiv 4y agoCite please?
- sirsinsalot 4y agoYou're misunderstanding the action of the medication and the defect in the brain of adhd. Adhd is an abnormal density of dopamine transporter. Receptor density might increase, but that's negligible in the system compared to the starting density of transporters at therapeutic doses.