I'm not really sure what minimal damage regions are but I can imagine a case in something like scrolling where a context aware approach would beat a general pur

I'm not really sure what minimal damage regions are but I can imagine a case in something like scrolling where a context aware approach would beat a general purpose block based video codec, especially h264 at higher resolutions. With a small macroblock size a large enough vertical scroll might cause the encoder to send fresh pixel data for the blocks with a large enough vertical translation. A context aware encoder would not only not miss the translation but also know where to begin its search algorithm, improving the encode speed. In another case a window coming into view, misaligned to a macroblock boundary, would need to send more data than a context aware encoder that simply sent the window pixels and the location to draw them.