https://arxiv.org/abs/1607.02318 https://arxiv.org/abs/1607.02318 is a widely cited paper that argues that simple and orthogonal ISA's are preferable, as fusion

https://arxiv.org/abs/1607.02318 https://arxiv.org/abs/1607.02318 is a widely cited paper that argues that simple and orthogonal ISA's are preferable, as fusion can fix up those common cases like more complicated addressing modes that other ISA's have in the base ISA.