From experience, that hasn’t been true. I’ll give an example. Rdkit[0] went for years without being able to be released via pypi and could only be installed ea

From experience, that hasn’t been true. I’ll give an example. Rdkit[0] went for years without being able to be released via pypi and could only be installed easily via conda[1]. Despite this, it thrived enough as a project that users got its postgresql extension to be part of AWS Aurora[2] in 2020, which means wide adoption before rdkit had managed to figured out how to be distributed by pypi in 2021. There are open source projects like this all over the place, thriving outside the centralized repos. [0] https://rdkit.org https://rdkit.org [1] https://stackoverflow.com/questions/58199504/how-to-install-a-package-rdkit-from-conda-with-pip https://stackoverflow.com/questions/58199504/how-to-install-... [2] https://aws.amazon.com/about-aws/whats-new/2020/09/amazon-aurora-postgresql-supports-rdkit-extension/ https://aws.amazon.com/about-aws/whats-new/2020/09/amazon-au...