3 ms·
This seems like a setup for a gotcha, or did you label it as novel in your comment without knowing the answer to this question? Prior to the COVID-19 pandemic,
by dpedu 4y ago
This seems like a setup for a gotcha, or did you label it as novel in your comment without knowing the answer to this question?
Prior to the COVID-19 pandemic, mRNA vaccines targeting infectious diseases including HIV-1, rabies, Zika and influenza were already in clinical trials, as were mRNA vaccines targeting multiple hematologic and solid organ malignancies (Pardi, 2018).
- sokoloff 4y agoYou seem to be the one arguing that, with respect to uncertainties about possible side effects, mRNA vaccine deployment was not novel. It's not a convoluted argument; it's a straight-forward "I think it was novel [with respect to the unknowability of low-percentage side-effects]". If you have data that we did have a widely deployed vaccine using that tech (which I think, but don't 100.000% know, hadn't happened), then I'm interested to learn that.
- dpedu 4y agoJust how wide do you want "widely" to be? Are you trying to say we don't learn anything about this subject from clinical trials? I'm sure data related to the many clinical trials I mentioned is available.
- sokoloff 4y agoWide enough to hit the vast majority of ages, races, health statuses [pregnancy, cancer, other medications/medical conditions] to which the vaccine will be deployed and in numbers sufficient that 1 in 10K [or even 1 in 1K] frequency adverse reactions would be reasonably sure to have shown up. (1 in 10K across an 8B population is 800K adverse reactions; 1 in 1K is 8 million people...). Are you trying to say that we learn everything about this subject from clinical trials?