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As soon as the EUAs were issued, the vaccine manufacturers shut down clinical trial followup and, in many cases, allowed vaccination of the control branch of th
by wrycoder 4y ago
As soon as the EUAs were issued, the vaccine manufacturers shut down clinical trial followup and, in many cases, allowed vaccination of the control branch of the trials. Same for Paxlovid, where support for independent trials was refused.
- throwaway049 4y ago'allowed vaccination of the control branch' People in the control branch were told they were controls so that they had the option to get the newly-authorized vaccine for real. Standard practice for trials that go well.
- wrycoder 4y agoAnd so the long term effects of the treatment are uncontrolled. I think it's standard practice for therapeutics, but not for vaccines?
- pieter_mj 4y agoI, probably with many others, didn't realize this could be the consequence of an EUA until you mentioned it here. Thank you.
- snowwrestler 4y agoIt's not specific to EUA, this is commonly done when a Phase 3 trial shows a clear benefit. Essentially, once you're sure a medicine confers a real benefit, it becomes unethical to deny it to the control branch any longer.
- oezi 4y agoCitation?