Beter decisions about what to collect would, for example be A higher ratio of 'progress towards definitive answer' per dollar spend. Perhaps with a smidge of,

Beter decisions about what to collect would, for example be A higher ratio of 'progress towards definitive answer' per dollar spend. Perhaps with a smidge of, making people more likely to participate. Better ways to collect data has two routes for improvement. The boring one is automation. Just chuck smart watches on the subjects and have those track data on a hourly basis rather than monthly doctor visits. The exciting but scary one is standardized health records keeping that allows tracking outcomes. That also requires a process for analyzing that data on a national scale whilst preserving privacy. The crypto to do that exists, but getting trust will be difficult. There could be other ways of doing analysis without hurting privacy too much. This system could then be used whenever 'real-world-data' is appropriate. Importantly, it could also be used to track data from the randomized medical trials!