3 ms·
> But I suspect that they are unlikely to mutate an already mutated gene Could you elaborate? I'd like to understand what you mean, as I don't work on onc. Are
by suslik 4y ago
> But I suspect that they are unlikely to mutate an already mutated gene
Could you elaborate? I'd like to understand what you mean, as I don't work on onc. Aren't recurring mutations in response to treatment in f.e EGFR is the reason we keep developing multiple generations of small molecule therapies for it?
- dm319 4y agoYes, I didn't mean impossible, I just mean compared to accumulating new mutations elsewhere, and compared to downregulating surface proteins (which can be the issue in CAR-T).