Only tangentially my field, but both cytotoxic and helper T-cells bind on antigens, and indeed this work CRISPR edited anything with a TCR to their (3) preferre

Only tangentially my field, but both cytotoxic and helper T-cells bind on antigens, and indeed this work CRISPR edited anything with a TCR to their (3) preferred, cancer-targeting receptors (for each patient). The press release has a few more details (in addition to the Nature paper): https://pactpharma.com/news/pact-pharma-reports-data-from-first-clinical-study-using-crispr-to-substitute-a-gene-in-patients-immune-cells-to-treat-cancer/ https://pactpharma.com/news/pact-pharma-reports-data-from-fi...