30 ms·
Comprehensive accessible review here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/ The virus ap
by photochemsyn 4y ago
Comprehensive accessible review here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/
The virus apparently just wrecks the immune system right off the bat, allowing it to rampage throughout the body unchecked. Hence immune-system-support therapies are being worked on:
> "EBOV is able to evade innate and adaptive (both humoral and cellular) responses by encoding for multiple viral proteins that inhibit both type-I IFNs synthesis and response, by masking viral epitopes by glycosylation processes, by deregulating inflammatory response, by preventing DC maturation, thus resulting in a catastrophic failure of innate and adaptive immunity. Thus host factors have a key role for viral replication and release, and may represent good targets for therapeutic strategies."
The for-profit pharmaceutical system isn't that interested in this, as not many people or governments in Africa have the funds to pay for research, production, and what is it now, a guaranteed 15%+ profit margin?
- Blahah 4y ago"right off the bat" is unfortunately apt for ebola!