Agree, this is something that would take centuries probably. The most plausible way to do it would be including extra copies of TP53 under appropriate regulatio

Agree, this is something that would take centuries probably. The most plausible way to do it would be including extra copies of TP53 under appropriate regulation. This has been done in mice and they seem fine. Unfortunately, it would need to be done in larger animals progressively to show safety, which would take 20 - 30 years for a full lifecourse study in primates (unfortunate because we are experimenting on primates). Even longer if their lifespan is increased. After that, we would be left with a conundrum, which is the ethics of modifying the germline of an embryo. I don't know what the solution is there. Maybe it could be justified in families with an elevated risk of cancer, or Mars colonists for whom any sort of cancer will be a death sentence. Another option would be an as yet uninvented way to edit the genome, but provide an 'Undo' function to reverse the edit, say by giving some small molecule.